Clinical presentation and short-term outcomes of dogs ≥15 kg with extrahepatic portosystemic shunts.

Objective: To describe demographics, clinical presentation, shunt anatomy, clinical progression, and complications in large dogs ≥15 kg with single extrahepatic portosystemic shunts (EHPSS) treated with or without surgery.

Study Design: Multicenter retrospective (10 university hospitals, one private referral institution).

Animals: Dogs ≥15 kg (n = 63).

Case report: Clitoral adenocarcinoma in a mixed-breed female dog.

A 9-year-old, spayed female, mixed-breed dog was initially presented for evaluation of chronic dermatitis on the nasal planum, where a clitoral mass was discovered as an incidental finding during the exam. No further investigation of the clitoral mass was undertaken due to other significant dermal lesions and the lack of clinical significance of the mass at the time. However, ~1 month later, the dog was presented to the Emergency Service for bleeding from the vulva.

Histotripsy ablation for the treatment of feline injection site sarcomas: a first-in-cat feasibility study.

Purpose: Feline soft tissue sarcoma (STS) and injection site sarcoma (fISS) are rapidly growing tumors with low metastatic potential, but locally aggressive behavior. Histotripsy is a non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. In this study, we investigated the safety and feasibility of histotripsy to treat fISS using a custom 1 MHz transducer.

Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs.

Osteosarcoma (OS) is a malignant bone tumor treated by limb amputation or limb salvage surgeries and chemotherapy. Histotripsy is a non-thermal, non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. Recent ex vivo and in vivo pilot studies have demonstrated the ability of histotripsy for ablating OS but were limited in scope.

Sternohyoideus-sternothyroideus muscle flap to reconstruct oronasal fistulas due to maxillary cancer in four dogs.

Objective: To describe the repair of oronasal fistulas in dogs treated for maxillary cancer, with a novel sternohyoideus-sternothyroideus muscle flap, and to report the outcome.

Animals: Client-owned dogs (n = 4) with oronasal fistulas related to cancer.

Study Design: Short case series.

Retroperitoneal myxosarcoma in a cat.

This report details a retroperitoneal myxosarcoma in a cat that exhibited extremely aggressive biological behavior. An exploratory midline celiotomy revealed a left-sided retroperitoneal mass firmly adhered to the hypaxial musculature. Histopathological evaluation identified the mass as a myxosarcoma.

Histotripsy Ablation of Spontaneously Occurring Canine Bone Tumors In Vivo.

Objective: Osteosarcoma (OS) is a devastating primary bone tumor in dogs and humans with limited non-surgical treatment options. As the first completely non-invasive and non-thermal ablation technique, histotripsy has the potential to significantly improve the standard of care for patients with primary bone tumors.

Introduction: Standard of care treatment for primary appendicular OS involves surgical resection via either limb amputation or limb-salvage surgery for suitable candidates.

Long-term postoperative effects of administration of allogeneic blood products in 104 dogs with hemangiosarcoma.

Objective: To determine the influence of administering allogeneic blood products (ABP) on the progression of hemangiosarcoma in dogs.

Study Design: Multi-institutional, retrospective study.

Sample Population: One hundred four dogs with hemangiosarcoma that survived until postoperative discharge from the hospital.

Removal of hemangiosarcoma cells from canine blood with a cell salvage system and leukocyte reduction filter.

Objective: To determine the ability of an intraoperative cell salvage (IOCS) system and a leukocyte reduction filter (LRF) to remove hemangiosarcoma (HSA) cells from canine blood.

Study Design: Cultured HSA cells were added to canine blood to simulate intraoperative hemorrhage and address hemoabdomen from ruptured splenic HSA. The blood/HSA cell mixture was processed through an IOCS, followed by LRF processing.