Publications by authors named "Brittany C MacIntyre"
Article Synopsis
- The Omega-3 Index (O3I) measures the levels of important fatty acids EPA and DHA in red blood cells, linked to various health benefits, but is not widely used for monitoring.
- In a study with 88 participants, researchers explored using urine samples to track changes in O3I after 12 weeks of supplementation with either olive oil (as a control), EPA, or DHA.
- They discovered a potential new urinary biomarker, CPCA, that significantly increased with EPA and DHA and could effectively differentiate between supplementation groups, suggesting a new non-invasive way to assess omega-3 status.
Optimal dietary intake of omega-3 long-chain polyunsaturated fatty acids (n3-LCPUFAs) is critical to human health across the lifespan. However, omega-3 index (O3I) determination is not routinely assessed due to complicated procedures for n3-LCPUFA analysis from the phospholipid (PL) fraction of erythrocytes. Herein, a high-throughput method for lipidomics based on multisegment injection-nonaqueous capillary electrophoresis-mass spectrometry was applied to identify circulating PLs as surrogate biomarkers of O3I in two randomized placebo-controlled trials.
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