Publications by Brittany B Lanser

Publications by authors named "Brittany B Lanser"

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Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents.

Philip M Kubara Sophie Kernéis-Golsteyn Aurélie Studény Brittany B Lanser Laurent Meijer

Biochem J

September 2012

In the present paper, we report that mitosis is a key step in the cellular response to genotoxic agents in human cells. Cells with damaged DNA recruit γH2AX (phosphorylated histone H2AX), phosphorylate Chk1 (checkpoint kinase 1) and arrest in the G2-phase of the cell cycle. Strikingly, nearly all cells escape the DNA damage checkpoint and become rounded, by a mechanism that correlates with Chk1 dephosphorylation.

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