Persistent Head and Neck Cancer Following First-Line Treatment.

Following first-line treatment of head and neck cancer (HNC), persistent disease may require second-line treatment. All patients with HNC treated between 2008 and 2016 were included. Second-line treatment modalities and survival of patients were analyzed.

Standard fractionation intensity modulated radiation therapy (IMRT) of primary and recurrent glioblastoma multiforme.

Background: Intensity-modulated radiation therapy (IMRT) affords unparalleled capacity to deliver conformal radiation doses to tumors in the central nervous system. However, to date, there are few reported outcomes from using IMRT, either alone or as a boost technique, for standard fractionation radiotherapy for glioblastoma multiforme (GBM).

Methods: Forty-two patients were treated with IMRT alone (72%) or as a boost (28%) after 3-dimensional conformal radiation therapy (3D-CRT).

Optimized conformal paraaortic lymph node irradiation is not associated with enhanced renal toxicity.

Background And Purpose: For patients with gynecologic carcinomas, irradiation of paraaortic lymph nodes (PLNs) is a routine treatment concept. Planning target volumes (PTVs) individually optimized by radiation field delineations along the big vessels permit the inclusion of at least 97% of potentially involved PLNs. However, this novel treatment technique might increase radiation-induced nephrotoxicity.

Single-institution results of primary external-beam radiation for the treatment of t1-t3 prostate cancer.

Purpose: To evaluate survival and toxicity rates after primary external-beam radiation for the treatment of prostate cancer.

Patients And Methods: Data of 306 patients treated with conformal external beam radiation between 1996 and 2001 were collected. These were evaluated in terms of overall, cause-specific and disease-free survival as well as toxicity.

Austrian breast cancer patterns-of-care studies PCS93 and PCS01 versus PCS85 to identify changes in national practice.

Purpose: To determine the patterns of evaluation and treatment in Austrian breast cancer patients treated with surgery and radiotherapy in 1993 (PCS93) and 2001 (PCS01), and to compare these with the results of PCS85.

Material And Methods: According to the evaluation process of the Austrian PCS85, ten randomly selected patient charts from every Austrian radiotherapy center from 1993 (n=100) as well as 2001 (n=120) were reviewed. The work-up included surgical and (histo)pathologic information, systemic therapy and detailed information on radiation therapy.

Competing irradiation techniques for para-aortic lymph nodes: dose distribution and NTCP for the kidney.

Purpose: Partial coirradiation of both kidneys is an unavoidable consequence of adequate dose delivery in radiation therapy of para-aortic lymph nodes (PLN). Depending on total dose anteroposterior/posteroanterior (AP/PA), opposed-fields or multifield techniques are used. To optimize the treatment of potentially tumor-affected PLN with minimal kidney involvement, we calculated normal tissue complication probabilities (NTCPs) of coirradiated kidneys for four common irradiation techniques used in the PLN area.