Publications by authors named "Brindha Durairaj"
Article Synopsis
- Epilepsy affects about 70 million people globally, with roughly 30% of patients not responding to current antiepileptic drugs, underscoring the need for more effective treatments.
- The study investigates Necrostatin-1 (Nec-1), a selective RIPK1 inhibitor, for its potential anticonvulsant effects in zebrafish larvae with PTZ-induced seizures.
- Results showed that Nec-1 helped restore normal behavior, decreased inflammatory cytokine levels, and improved GABA receptor expression, indicating its potential as a new treatment approach for epilepsy.
Cardiovascular diseases (CVD) are a range of diseases, pointing the functional hindrances in the heart and blood vessels of the human system that contributes to 48.6 % of the world's adult death rate. The diagnosis of CVD relies upon the Electro Cardio Gram (ECG) and detection of muscle markers such as troponins.
View Article and Find Full Text PDFEvaluation of Developmental Toxicity and Oxidative Stress Caused by Zinc Oxide Nanoparticles in Zebra Fish Embryos/ Larvae.
Appl Biochem Biotechnol
August 2024
Article Synopsis
- The study focuses on synthesizing non-toxic zinc oxide nanoparticles (ZnO NPs) from marine algae (Sargassum polycystum) due to concerns about their environmental impact and lack of regulation.* -
- Characterization methods showed that these nanoparticles are rod-shaped with an average diameter of about 100 nm and exhibit specific crystal properties.* -
- Toxicity tests using zebra fish larvae indicated that ZnO NPs caused developmental delays, increased deformities, oxidative stress, and changes in cellular activity, highlighting potential risks even with green synthesis methods.*
Objective: Collagen is a fibrous protein that is primarily used in the pharmaceutical and biomedical industries. This study isolates and characterizes type-1 collagen from (scales, skin, and muscle).
Materials And Methods: Collagen was isolated from using two methods: acid-solubilized collagen and pepsin-solubilized collagen.
The anticancer activity of malvidin was studied in Dalton's lymphoma ascites (DLA)-induced solid and ascitic tumor mice models. Malvidin is a natural compound belonging to the family of O-methylated anthocyanidin and plays a predominant role in regulating both short- and long-term cellular activities. Animals were injected with DLA cells (1.
View Article and Find Full Text PDFIn Vivo Anticancer Activity of Biosynthesized Zinc Oxide Nanoparticle using Turbinaria conoides on a Dalton's Lymphoma Ascites Mice Model.
J Environ Pathol Toxicol Oncol
August 2018
In the present study, we aimed to evaluate the anticancer effect of zinc oxide nanoparticles (ZnO-NPs) synthesized from Turbinaria conoides against a murine model of Dalton's lymphoma ascites (DLA). Nanoparticles were synthesized from the hydroethanolic extract of T. conoides (HETC).
View Article and Find Full Text PDF