Publications by authors named "Brindha Durairaj"

Article Synopsis
  • Epilepsy affects about 70 million people globally, with roughly 30% of patients not responding to current antiepileptic drugs, underscoring the need for more effective treatments.
  • The study investigates Necrostatin-1 (Nec-1), a selective RIPK1 inhibitor, for its potential anticonvulsant effects in zebrafish larvae with PTZ-induced seizures.
  • Results showed that Nec-1 helped restore normal behavior, decreased inflammatory cytokine levels, and improved GABA receptor expression, indicating its potential as a new treatment approach for epilepsy.
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Cardiovascular diseases (CVD) are a range of diseases, pointing the functional hindrances in the heart and blood vessels of the human system that contributes to 48.6 % of the world's adult death rate. The diagnosis of CVD relies upon the Electro Cardio Gram (ECG) and detection of muscle markers such as troponins.

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Article Synopsis
  • The study focuses on synthesizing non-toxic zinc oxide nanoparticles (ZnO NPs) from marine algae (Sargassum polycystum) due to concerns about their environmental impact and lack of regulation.* -
  • Characterization methods showed that these nanoparticles are rod-shaped with an average diameter of about 100 nm and exhibit specific crystal properties.* -
  • Toxicity tests using zebra fish larvae indicated that ZnO NPs caused developmental delays, increased deformities, oxidative stress, and changes in cellular activity, highlighting potential risks even with green synthesis methods.*
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Objective: Collagen is a fibrous protein that is primarily used in the pharmaceutical and biomedical industries. This study isolates and characterizes type-1 collagen from (scales, skin, and muscle).

Materials And Methods: Collagen was isolated from using two methods: acid-solubilized collagen and pepsin-solubilized collagen.

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The anticancer activity of malvidin was studied in Dalton's lymphoma ascites (DLA)-induced solid and ascitic tumor mice models. Malvidin is a natural compound belonging to the family of O-methylated anthocyanidin and plays a predominant role in regulating both short- and long-term cellular activities. Animals were injected with DLA cells (1.

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In the present study, we aimed to evaluate the anticancer effect of zinc oxide nanoparticles (ZnO-NPs) synthesized from Turbinaria conoides against a murine model of Dalton's lymphoma ascites (DLA). Nanoparticles were synthesized from the hydroethanolic extract of T. conoides (HETC).

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