Publications by authors named "Brigitte Dananche"
Article Synopsis
- Researchers faced challenges linking job data from different classifications to the Occupational Asthma-specific Job-Exposure Matrix (OAsJEM), which uses the ISCO88 classification, necessitating the development of a crosswalk for the CONSTANCES cohort coded with PCS2003.
- The crosswalk was created through a collaborative effort involving skilled and novice coders who developed strategies to convert jobs from PCS2003 to ISCO88, refining their results through consensus meetings.
- The finalized crosswalk established 998 job matches, revealing significant variability in the initial proposals from different coders and showcasing the complexity in transcoding occupational classifications.
Objectives: Etiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men.
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- - The study investigates the link between chronic occupational exposure to irritants, such as disinfectants and solvents, and asthma in a large cohort of French adults, focusing on both men and women.
- - Findings indicate that women show a significant association between current asthma and lifetime exposure to irritants, DCPs, and solvents, while men only showed a link to DCPs.
- - The research concludes that lifetime exposure to these irritants is connected to higher asthma symptom scores, highlighting the need for consideration of occupational exposures in asthma management.
Background: Testicular germ cell tumors (TGCT) are the most frequent cancer in young men in developed countries. Parental occupational exposures during early-life periods are suspected to increase TGCT risk. The objective was to estimate the association between parental occupations at birth and adult TGCT.
View Article and Find Full Text PDFObjectives: The etiology of testicular germ cell tumors (TGCT) is suspected to be related to prenatal environmental risk factors. Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. The aim of this study was to examine the association between parental occupational exposure to solvents and TGCT risk among their offspring.
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- Testicular germ cell tumors (TGCT) are the most common cancer in young men and their incidence has significantly increased over the past 40 years, prompting this study to investigate the link between certain occupations and TGCT risk in men aged 18-45.
- The TESTIS study, conducted in metropolitan France from 2015 to 2018, included 454 TGCT cases and 670 controls, collecting comprehensive job histories, and analyzed the data using statistical methods to estimate odds ratios for different occupations.
- Results indicated a higher TGCT risk in agricultural workers, salesmen, and electrical fitters, suggesting the need for further research to uncover specific agents or chemicals contributing to this increased risk in these professions.
Article Synopsis
- About 15% of women in developed countries are exposed to solvents at work during pregnancy, but the effects on fetal growth vary based on the type of solvent (oxygenated, petroleum, chlorinated).
- The study aims to explore how maternal exposure to different solvent families during pregnancy impacts the risk of neonatal outcomes, such as being small for gestational age (SGA) or having low birthweight.
- Results indicate that exposure to petroleum and oxygenated solvents is linked to a higher risk of SGA and lower birth weights and head circumferences, highlighting potential risks of specific solvent types during pregnancy.
Testicular cancer is the most common cancer in young men. Its causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated paternal occupational exposure to heavy metals and welding fumes and the risk of testicular germ cell tumors (TGCT) in their offspring.
View Article and Find Full Text PDFAim: The biological mechanisms of work-related asthma induced by irritants remain unclear. We investigated the associations between occupational exposure to irritants and respiratory endotypes previously identified among never asthmatics (NA) and current asthmatics (CA) integrating clinical characteristics and biomarkers related to oxidative stress and inflammation.
Methods: We used cross-sectional data from 999 adults (mean 45 years old, 46% men) from the case-control and familial Epidemiological study on the Genetics and Environments of Asthma (EGEA) study.
Objectives: Trichloroethylene (TCE) is suspected of association with elevated risk of cervical cancer. A case-control study was performed in a geographical area in which occupational TCE exposure is high. The study objective was to analyze the correlation between occupational TCE exposure and cervical cancer (including precancerous conditions).
View Article and Find Full Text PDFObjectives: Matgéné is a program to develop job-exposure matrices (JEMs) adapted to the general population in France for the period since 1950. The aim is to create retrospective exposure assessment tools for estimating the prevalence of occupational exposure to various agents that can then be correlated to health-related parameters.
Methods: JEMs were drawn up by a team of six industrial hygienists who based their assessments on available occupational measurement, economic and statistical data, and several thousand job descriptions from epidemiological studies performed in France since 1984.
Objectives: To describe urine levels of metabolites of glycol ethers and chlorinated solvents in a sample of pregnant women from the general population, to study their occupational and non-occupational determinants and to compare them with the results of indirect assessment methods of solvent exposure.
Methods: A sample of 451 pregnant women was randomly selected from a general population cohort. At inclusion, the women in this sample completed a self-administered questionnaire about their social and medical characteristics, occupation and exposure to different products at work and in non-occupational activities.
Objectives: Investigating the role of occupational exposure to solvents in the occurrence of lymphoid neoplasms (LNs) in men.
Methods: The data were generated by a French hospital-based case-control study, conducted in six centres in 2000-2004. The cases were incident cases aged 18-75 years with a diagnosis of LN.