Temozolomide for recurrent or progressive high-grade malignant glioma: results of an Austrian multicenter observational study.

Background: The use of chemotherapy in patients with malignant gliomas has remained a controversial issue even after the publication of favorable study data and a meta-analysis. The present study was initiated to support the use of chemotherapy in patients with relapsed high-grade gliomas (HGG).

Patients And Methods: Six Austrian centers recruited 43 patients with histologically confirmed HGG at first recurrence.