Publications by authors named "Brigita Gradauskiene Sitkauskiene"
Article Synopsis
- The study investigates the impact of genetic variations in VDBP on vitamin D levels and asthma susceptibility across different ethnic groups.
- Findings indicate significant ethnic differences in vitamin D levels, with asthmatic individuals generally having lower levels compared to non-asthmatics.
- VDBP polymorphisms were linked to asthma risk in the Latvian group but not in others, highlighting the complexity of these associations across diverse populations.
Background: In order to improve the control of atopic diseases, it is important to clarify the pathogenesis of atopy and identify its various triggers. Single nucleotide polymorphisms (SNPs) of the vitamin D receptor gene () may impact atopy. The aim of this study was to investigate the possible associations between SNPs and vitamin D, total IgE, and eosinophils in atopy.
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- Bronchial asthma (BA) varies in prevalence worldwide, leading researchers to explore both genetic and environmental factors that contribute to this condition.
- Vitamin D plays a crucial role in regulating the immune system and may influence asthma risk through variations in the vitamin D receptor (VDR) gene.
- This study specifically examines the interactions among genetic variations, serum vitamin D levels, and geographic differences, revealing that certain genetic factors can either increase or decrease asthma risk in Eastern European populations compared to East Asians.