Lymphotropic adamantinoid trichoblastoma.

We report a lymphotropic adamantinoid trichoblastoma in a 14-year-old girl. This is a rarely reported skin adnexal tumor in adolescent patients. The clinical, histologic, and immunohistochemical features of this tumor are described.

Chemical determinants of the rat electro-olfactogram.

The chemical properties that determine the distribution of the electro-olfactogram were studied after exposure of a large area of the rat olfactory epithelium. Multiple electrodes were placed along the rostral border of endoturbinate IV on the midline of the nasal cavity. This array of electrodes spanned a region containing the four receptor gene expression zones described for the rat.

Vitamin D receptor as a candidate tumor-suppressor gene in severe hyperparathyroidism of uremia.

Most chronic renal failure patients with severe refractory hyperparathyroidism harbor at least one monoclonal parathyroid tumor, but the specific acquired genetic defects that confer this clonal selective advantage remain poorly understood. Somatic inactivation of the vitamin D receptor (VDR) gene could contribute to clonal outgrowth, because a parathyroid cell containing this lesion would have an impaired response to the antiproliferative influence of 1,25-dihydroxyvitamin D3. Furthermore, diminished expression of VDR protein has been described in uremia-associated parathyroid tumors.

A functional map in rat olfactory epithelium.

Multiple (four or eight) electrode arrays were placed for simultaneous electro-olfactogram (EOG) recordings of responses to a series of odors applied directly to the olfactory epithelium. Three different surfaces of the epithelium were exposed in rats immediately after death by anesthetic overdose. We tested three terpene compounds (carvone, limonene and 1,8-cineole) across the epithelium along the medial surface of the endoturbinate bones.

A hip wear simulator for the evaluation of biomaterials in hip arthroplasty components.

A multistation (8-station) hip simulator has been designed and tested that provides a practical imitation of the motions and loads seen by the hip joint during a typical walking cycle. A biaxial rocking motion of +/- 23 degrees is synchronized with the respective resultant forces of the extension-flexion (heel-strike to toe-off) movements of the leg. This particular simulator provides a practical engineering in vitro implementation of the walking cycle.