Publications by authors named "Bridgette Warner"
Noncoding Vault RNA1-1 Impairs Intestinal Epithelial Renewal and Barrier Function by Interacting With CUG-binding Protein 1.
Cell Mol Gastroenterol Hepatol
December 2024
Article Synopsis
- The study investigates the role of small noncoding vault RNA (vtRNA1-1) in the intestinal epithelium, focusing on its impact on epithelial renewal and barrier function.
- It found that elevated levels of vtRNA1-1 are associated with mucosal injury and increased gut permeability in shock patients and septic mice, indicating a negative effect on intestinal health.
- The research also suggests that vtRNA1-1 inhibits the expression of key proteins involved in gut barrier function by interacting with CUG-binding protein 1 (CUGBP1), highlighting a potential mechanism for gut mucosal disruption in critical illness.
Rapid self-renewal of the intestinal epithelium requires the activity of intestinal stem cells (ISCs) that are intermingled with Paneth cells (PCs) at the crypt base. PCs provide multiple secreted and surface-bound niche signals and play an important role in the regulation of ISC proliferation. Here, we show that control of PC function by RNA-binding protein HuR via mitochondria affects intestinal mucosal growth by altering ISC activity.
View Article and Find Full Text PDFVault RNAs (vtRNAs) are small noncoding RNAs and highly expressed in many eukaryotes. Here, we identified vtRNA2-1 as a novel regulator of the intestinal barrier via interaction with RNA-binding protein HuR. Intestinal mucosal tissues from patients with inflammatory bowel diseases and from mice with colitis or sepsis express increased levels of vtRNAs relative to controls.
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