Publications by authors named "Bridget McGuire"
Background: Sarcomatoid urothelial cancer of the bladder (SBC) is a rare, but aggressive histological subtype for which novel treatments are needed.
Objective: We evaluated the clinical activity and safety of neoadjuvant cisplatin plus gemcitabine plus docetaxel (CGD) in muscle-invasive patients with SBC and assessed SBC tumor biology by whole transcriptome RNA sequencing.
Methods: A single-institution, retrospective analysis of muscle-invasive SBC patients treated with neoadjuvant CGD with molecular analysis.
Article Synopsis
- A phase 1 trial was conducted to assess the safety and early effectiveness of durvalumab (D) alone and in combination with BCG or EBRT for treating patients with non-muscle-invasive bladder cancer (NMIBC) who did not respond to standard BCG therapy.
- Patients received D every 3 weeks for eight cycles, with some also receiving BCG or EBRT, and outcomes were measured using cystoscopy, urine cytology, and bladder biopsies at 3 and 6 months.
- Results showed that 64% of patients achieved a complete response at 3 months, with notable responses in combination therapy groups, suggesting that D combined with BCG or EBRT is safe and warrants further investigation.
Expression of Nectin-4 in Bladder Urothelial Carcinoma, in Morphologic Variants, and Nonurothelial Histotypes.
Appl Immunohistochem Mol Morphol
September 2021
The antibody-drug conjugate enfortumab-vedotin acts by targeting nectin-4, a protein that is nearly ubiquitously expressed in conventional urothelial cancer. However, expression of nectin-4 in morphologic variants of urothelial carcinoma and nonurothelial histotypes was unknown. Immunohistochemistry for nectin-4 using was performed on 169 patients including 83 with nonmuscle invasive bladder cancer and 86 patients with muscle invasive bladder cancer.
View Article and Find Full Text PDFHuman monocytic ehrlichiosis is caused by a tick-transmitted rickettsia, Ehrlichia chaffeensis. We recently reported that E. chaffeensis grown in tick cells expresses different proteins than bacteria grown in macrophages.
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