Publications by authors named "Bridget M Holle"
Acta Neuropathol Commun
September 2024
Article Synopsis
- The study analyzed genetic alterations in cerebrospinal fluid (CSF) from 711 patients to help classify CNS cancers and guide targeted therapies.
- They found detectable circulating tumor DNA (ctDNA) in over half of CSF samples from patients with CNS tumors, while none was found in samples from patients without CNS tumors.
- The research also revealed clonal evolution and resistance mechanisms over time, with ctDNA presence linked to poorer overall survival rates for these patients.
