From anxiety to control: Mask-wearing, perceived marketplace influence, and emotional well-being during the COVID-19 pandemic.

Mask-wearing has been one of the most prominent, conflicted, and deeply divided issues in the United States during the COVID-19 pandemic. Across two studies, we seek to understand how beliefs and behaviors around mask-wearing are associated with the relationship between anxiety about the coronavirus and feelings of control over one's health outcomes during the pandemic. In Study 1, we find that beliefs in the response efficacy of mask-wearing moderate the relationship between anxiety and control.

Generic Pharmaceuticals as a Source of Diuretic Contamination in Athletes Subject to Sport Drug Testing.

This paper describes nine instances of positive anti-doping tests that could be accounted for by the use of permitted generic prescription drugs contaminated with diuretics, which are prohibited in sport at all times under the WADA Prohibited List. The contamination levels found in the medications are reported and were below FDA limits for manufacturers that are based primarily on safety considerations. These cases demonstrate that great care must be taken to identify the source of low-level anti-doping positives for diuretics reported by WADA-accredited laboratories, and possibly other prohibited substances as well, in order to avoid sanctioning innocent athletes.

Too close for comfort, or too far to care? Finding humor in distant tragedies and close mishaps.

Humor is ubiquitous and often beneficial, but the conditions that elicit it have been debated for millennia. We examine two factors that jointly influence perceptions of humor: the degree to which a stimulus is a violation (tragedy vs. mishap) and one's perceived distance from the stimulus (far vs.

Structural remodeling and mechanical function in heart failure.

The cardiac extracellular matrix (ECM) is the three-dimensional scaffold that defines the geometry and muscular architecture of the cardiac chambers and transmits forces produced during the cardiac cycle throughout the heart wall. The cardiac ECM is an active system that responds to the stresses to which it is exposed and in the normal heart is adapted to facilitate efficient mechanical function. There are marked differences in the short- and medium-term changes in ventricular geometry and cardiac ECM that occur as a result of volume overload, hypertension, and ischemic cardiomyopathy.

Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization.

Alpha-calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. Despite well-documented pharmacological effects, its primary physiological role has thus far remained obscure. Increased lipid content, particularly in skeletal muscle and liver, is strongly implicated in the pathogenesis of insulin resistance, but the physiological regulation of organ lipid is imperfectly understood.

Regeneration of the heart in diabetes by selective copper chelation.

Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Although altered systemic regulation of transition metals in diabetes has been the subject of previous investigation, it is not known whether changed transition metal metabolism results in heart disease in common forms of diabetes and whether metal chelation can reverse the condition. We found that administration of the Cu-selective transition metal chelator trientine to rats with streptozotocin-induced diabetes caused increased urinary Cu excretion compared with matched controls.

Dynamic baroreflex control of blood pressure: influence of the heart vs. peripheral resistance.

The aim in the present experiments was to assess the dynamic baroreflex control of blood pressure, to develop an accurate mathematical model that represented this relationship, and to assess the role of dynamic changes in heart rate and stroke volume in giving rise to components of this response. Patterned electrical stimulation [pseudo-random binary sequence (PRBS)] was applied to the aortic depressor nerve (ADN) to produce changes in blood pressure under open-loop conditions in anesthetized rabbits. The stimulus provided constant power over the frequency range 0-0.

Topical negative pressure for pressure ulcer management.

The use of negative pressure therapy has been reported previously in a variety of care settings, but not in spinal cord-injured (SCI) patients. These individuals are at greatly increased risk of pressure ulcer development because of many factors associated with their neurological deficit and the incidence of pressure ulcers is high among them. This small case series employed objective measures to evaluate the effectiveness of negative pressure therapy when used to prepare pressure ulcers for surgical closure.