Publications by authors named "Bridget Kennis"
Background: Diffuse midline gliomas (DMG), including brainstem diffuse intrinsic pontine glioma (DIPG), are incurable pediatric high-grade gliomas (pHGG). Mutations in the H3 histone tail (H3.1/3.
View Article and Find Full Text PDFThere was a typo in author Andrew Wahba's name in the initial online publication. The original article has been corrected.
View Article and Find Full Text PDFPurpose: Medulloblastoma (MB) is the most common malignant brain tumor in children. Recent studies have shown the ability of natural killer (NK) cells to lyse MB cell lines in vitro, but in vivo successes remain elusive and the efficacy and fate of NK cells in vivo remain unknown.
Methods: To address these questions, we injected MB cells into the cerebellum of immunodeficient mice and examined tumor growth at various days after tumor establishment via bioluminescence imaging.
Article Synopsis
- The study focuses on medulloblastomas (MBs) driven by the sonic hedgehog (SHH) pathway, highlighting the increased expression of the RE1-silencing transcription factor (REST) in the SHH-α and SHH-β subgroups, which are associated with poor patient outcomes.
- Using a transgenic mouse model, researchers found that REST interacts with GLI1, impacting tumor growth and neuronal maturation, notably showing a greater neuronal maturity in SHH-β tumors.
- Results indicate that REST contributes to chromatin remodeling and AKT activation in MBs, suggesting potential subgroup-specific therapeutic strategies for treating patients with these tumors.
Article Synopsis
- - Diffuse intrinsic pontine glioma (DIPG) is a deadly brain tumor in children, with a need for new treatments due to poor survival rates; this study focuses on the role of the Silencing Transcription Factor (REST) in DIPG pathology.
- - REST protein levels are found to be abnormally high in 21% of DIPG tumors; reducing REST in DIPG cell lines inhibits growth and decreases tumor formation in mouse models, while also negatively impacting tumor blood vessel development.
- - The research reveals that REST influences the production of a pro-angiogenic molecule, GREM-1, which is crucial for blood vessel growth in tumors; the findings suggest potential avenues for new therapies combining REST-targeting
Article Synopsis
- The study focuses on developing imaging techniques to track the distribution and effectiveness of natural killer (NK) cell immunotherapies for potential clinical use.* -
- The (19)F-MRI method is highlighted as an effective in vivo imaging approach due to its lack of background noise, allowing for clear observation of labeled NK cells.* -
- The research outlines a process for using (19)F nano-emulsion to label NK cells, combined with (19)F/(1)H magnetic resonance imaging, to facilitate their tracking in live subjects.*