A quantitative method for evaluating cortical responses to electrical stimulation.

Background: Electrical stimulation of the cortex using subdurally implanted electrodes can causally reveal structural connectivity by eliciting cortico-cortical evoked potentials (CCEPs). While many studies have demonstrated the potential value of CCEPs, the methods to evaluate them were often relatively subjective, did not consider potential artifacts, and did not lend themselves to systematic scientific investigations.

New Method: We developed an automated and quantitative method called SIGNI (Stimulation-Induced Gamma-based Network Identification) to evaluate cortical population-level responses to electrical stimulation that minimizes the impact of electrical artifacts.

Intrathecal analgesia for refractory cancer pain.

The use of intrathecal analgesics is an important treatment consideration for many patients with chronic cancer pain. This review describes the various opioid and nonopioid analgesics that have been used in this setting, including morphine, hydromorphone, fentanyl, meperidine, methadone, sufentanil, local anesthetics, clonidine, ketamine, baclofen, midazolam, betamethasone, and octreotide. We discuss available evidence for their analgesic and adverse effects.