Publications by authors named "Bricca R"
Objectives: To describe Staphylococcus lugdunensis prosthetic joint infection (PJI) management and outcome.
Methods: Adults with proven S. lugdunensis PJI were included in a multicentric retrospective cohort.
Introduction: Systemic nocardiosis is an infectious disease that is rarely associated with mediastinal lymph nodes.
Case Report: We report the case of a 72-year-old male patient treated with a high dose of oral corticosteroids for rheumatoid polyarthritis. This patient presented with rapid overall deterioration associated with mediastinal lymph nodes.
Daptomycin is a candidate for therapeutic drug monitoring (TDM). The objectives of this work were to implement and compare two pharmacometric tools for daptomycin TDM and precision dosing. A nonparametric population PK model developed from patients with bone and joint infection was implemented into the BestDose software.
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- Daptomycin is commonly used for treating bone and joint infections, but its pharmacokinetics and optimal dosage haven't been well-explored, particularly when taken with rifampicin.* -
- The study analyzed data from 183 patients to determine how factors like sex and renal function affect daptomycin clearance and distribution, finding that women typically clear the drug 26% slower than men.* -
- Recommended dosages are 8 mg/kg/24 h for women and 10 mg/kg/24 h for men, but due to potential high trough levels, therapeutic drug monitoring is essential for safe and effective treatment.*
Background: To better understand the mechanisms of infection with nontuberculous mycobacteria (NTM) in patients with cystic fibrosis (CF), we explore different risk factors associated with NTM positivity in a meta-analysis.
Methods: Studies published before 31 July 2019 were selected from MEDLINE. Combined odds ratios (ORs) were calculated by pooling the ORs of each study.
Article Synopsis
- Daptomycin is a treatment option for bone and joint infections, and the ABCB1 gene, which affects drug transport, may impact how the drug works in patients due to genetic differences.
- Researchers analyzed data from 81 patients to study how factors like sex and specific genetic variations influence daptomycin's effectiveness and body clearance in the body.
- Findings suggest that higher daptomycin dosages than currently recommended might be needed, taking into account gender and genetic makeup, to ensure optimal treatment outcomes for patients with bone and joint infections.
Background: We evaluated the prevalence of non-tuberculous mycobacteria (NTM)-positive cultures among our cystic fibrosis (CF) center patients, reviewed risk factors for NTM positivity, and determined its impact on lung function evolution.
Methods: From 2009 to 2014, CF adults and children attending the CF center of Lyon (France) and having at least one positive NTM isolate were included. Each case was matched by age and gender with two CF patients with no NTM isolate (controls).