[Synthesis and biological activity of complexes of sulfonate-containing polyanions and gentamycin].

A series of copolymers of acrylamide (Am) with 2-acrylamido-2-methylpropanesulfonic acid (AmMPSA) and N-2-hydroxypropyl-methacrylamide (HPMA) with acrylic acid (AA) have been synthesized. Complexes of gentamycin in the base form with these polymers and dextran sulfate were obtained. It is established that both poly(AmMPCA) and its complex with gentamycin exhibit an antiviral activity in vitro against human A(H3N2) influenza virus and herpes simplex virus of type 1 (HSV-1).

[Content of ceruloplasmin and immunoglobulins of the main classes in the blood sera of patients with herpes virus infection].

In 35 patients with herpes virus infection (males and females aged 25 to 45 years) the content of ceruloplasmin and immunoglobulins of the main classes in the blood sera and the content of IgA in saliva at the stages of exacerbation and remission were evaluated. For control, a group of 35 healthy donors of the same ages were used. In patients with relapsing herpes virus infection even at the period of remission reliably higher levels of ceruloplasmin and immunoglobulins of the main classes were registered in comparison with those in the group of healthy donors.

[Resistance of herpes simplex virus to acyclovir: laboratory and clinical aspects].

Clinical isolates of the Herpes simplex virus had different susceptibility to acyclovir. Along with highly susceptible variants there were often isolated resistant variants and variants with intermediate susceptibility to the drug. All the clinical isolates were from the patients previously not treated with acyclovir.