Publications by authors named "Brianna Marion"
Plethysmography is employed in nonhuman primates (NHPs) to calculate respiratory minute volume and determine the exposure time required to deliver an aerosol at the target dose. Anesthetic drugs can impact breathing parameters like steady-state minute volume (SSMV) central to aerosol dosing. Alfaxalone-midazolam mixtures (AM) provide superior parameters for plethysmography in cynomolgus macaques.
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- Tick-borne diseases (TBDs) are a major health risk in both military and civilian contexts, heavily impacting low- and middle-income countries due to economic losses and tick management challenges.
- A study in Uganda's Cattle Corridor identified 4,425 hard ticks across seven species, with significant variations in species abundance and distribution based on season and location.
- The research found that while seasonality and location affected the prevalence of ticks, the overall infection rate of rickettsial pathogens remained consistent, highlighting the need for targeted tick management strategies.
Plethysmography is used in nonhuman primates (NHPs) to measure minute volume before aerosol exposure to an agent to calculate total time necessary in the exposure chamber. The consistency of respiratory parameters during the entire exposure time is paramount to ensuring dosing accuracy. Our study sought to validate an alfaxalone-midazolam (AM) anesthetic combination for use in aerosol studies.
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