Publications by authors named "Brianna M Blaine"
Neuropsychopharmacology
April 2024
Article Synopsis
- Psychiatric and obstetric diseases are increasingly interconnected, with shared risks related to G protein-coupled receptor signaling, particularly in the context of RGS2 mutations linked to preeclampsia and depression.
- Research on RGS2 knockout (KO) mice shows behaviors indicative of anxiety and depression, as well as changes in cerebrovascular structures, with notable sex-specific differences in serotonergic gene expression.
- Findings highlight that RGS2 KO mice display altered serotonin signaling and increased sensitivity to sertraline, particularly in females, suggesting potential shared biological mechanisms between psychiatric and obstetric disorders that could inform future therapeutic targets.
