Publications by authors named "Brianna Kaplanis"
The SARS-CoV-2 nucleocapsid protein (N protein) is critical in viral replication by undergoing liquid-liquid phase separation to seed the formation of a ribonucleoprotein (RNP) complex to drive viral genomic RNA (gRNA) translation and in suppressing both stress granules and processing bodies, which is postulated to increase uncoated gRNA availability. The N protein can also form biomolecular condensates with a broad range of host endogenous proteins including RNA binding proteins (RBPs). Amongst these RBPs are proteins that are associated with pathological, neuronal, and glial cytoplasmic inclusions across several adult-onset neurodegenerative disorders, including TAR DNA binding protein 43 kDa (TDP-43) which forms pathological inclusions in over 95% of amyotrophic lateral sclerosis cases.
View Article and Find Full Text PDFArticle Synopsis
- TDP-43 aggregation is linked to neurodegenerative diseases like ALS and FTD, making it a target for therapeutic approaches.* -
- Researchers discovered that the N-terminal fragment of RGNEF (NF242) can bind to TDP-43, preventing its interaction with RNA, which is crucial for its pathogenic role.* -
- Experiments in fruit flies and mice show that NF242 can improve symptoms and delay neurodegeneration associated with TDP-43, indicating potential as a treatment for related disorders.*