Publications by authors named "Brianna Gipson"
Article Synopsis
- Intestinal microbiota plays a crucial role in various diseases, and understanding diet's impact on it is essential for developing targeted therapies.
- A study analyzing meals and stool samples from 173 hospitalized patients found that higher caloric intake is linked to greater fecal microbiota diversity.
- The research indicates that consuming sweets or sugars while on antibiotics may disrupt the microbiome, suggesting that reducing sugar intake during such treatment could help protect gut health.
The thymus is essential for establishing adaptive immunity yet undergoes age-related involution that leads to compromised immune responsiveness. The thymus is also extremely sensitive to acute insult and although capable of regeneration, this capacity declines with age for unknown reasons. We applied single-cell and spatial transcriptomics, lineage-tracing and advanced imaging to define age-related changes in nonhematopoietic stromal cells and discovered the emergence of two atypical thymic epithelial cell (TEC) states.
View Article and Find Full Text PDFHematopoietic stem cells (HSCs) with multilineage potential are critical for effective T cell reconstitution and restoration of the adaptive immune system after allogeneic Hematopoietic Cell Transplantation (allo-HCT). The Kit subset of HSCs is enriched for multipotential precursors, but their T-cell lineage potential has not been well-characterized. We therefore studied the thymic reconstituting and T-cell potential of Kit HSCs.
View Article and Find Full Text PDFMicrobial transformation of bile acids affects intestinal immune homoeostasis but its impact on inflammatory pathologies remains largely unknown. Using a mouse model of graft-versus-host disease (GVHD), we found that T cell-driven inflammation decreased the abundance of microbiome-encoded bile salt hydrolase (BSH) genes and reduced the levels of unconjugated and microbe-derived bile acids. Several microbe-derived bile acids attenuated farnesoid X receptor (FXR) activation, suggesting that loss of these metabolites during inflammation may increase FXR activity and exacerbate the course of disease.
View Article and Find Full Text PDFArticle Synopsis
- T cells play a significant role in inflammatory diseases, and this study aimed to better understand the T cell receptor (TCR) repertoires found in various human tissues, especially in relation to graft-versus-host disease (GVHD).
- Researchers analyzed TCR repertoires in autopsied tissues from patients with and without GVHD, and also in mouse models, finding that similar tissue types had comparable TCR compositions, regardless of disease status.
- The study revealed that tissue resident T cells, primarily of donor origin, had unique signatures and characteristics that differed from those found in blood, emphasizing the need to focus on tissue analysis for insights into inflammatory conditions.
Genome Sequences of Six Cluster N Mycobacteriophages, Kevin1, Nenae, Parmesanjohn, ShrimpFriedEgg, Smurph, and SpongeBob, Isolated on Mycobacterium smegmatis mc155.
Microbiol Resour Announc
May 2019
The annotation of six cluster N phages (Kevin1, Nenae, Parmesanjohn, ShrimpFriedEgg, Smurph, and SpongeBob) reveals regions of genomic diversity, particularly within the central region of the genome. The genome of Kevin1 includes two orphams (genes with no similarity to other phage genes), with one predicted to encode an AAA-ATPase.
View Article and Find Full Text PDF