Development of an oral operant nicotine/ethanol co-use model in alcohol-preferring (p) rats.

Background: Alcohol abuse is frequently associated with nicotine (Nic) use. The current experiments were conducted to establish an oral operant ethanol + Nic (EtOH + Nic) co-use model and to characterize some aspects of EtOH + Nic co-use.

Methods: Rats were allowed to choose between EtOH alone or EtOH + Nic solutions.