Calcium/calmodulin regulates signaling at the α adrenoceptor.

Cardiovascular functions are mediated by multiple 7-pass transmembrane receptors whose activation promotes contraction or relaxation of the tissues. The α adrenoceptor type 1A plays important roles in the control of vascular tone and myocardial contractility via Ca-dependent actions. Here, using novel FRET-based biosensors, we identified a novel Ca-dependent interaction between calmodulin (CaM) and the human α adrenoceptor at the juxtamembranous region of its 4th submembrane domain (SMD4, a.

Estrogen Enhances Linkage in the Vascular Endothelial Calmodulin Network via a Feedforward Mechanism at the G Protein-coupled Estrogen Receptor 1.

Estrogen exerts many effects on the vascular endothelium. Calmodulin (CaM) is the transducer of Ca(2+) signals and is a limiting factor in cardiovascular tissues. It is unknown whether and how estrogen modifies endothelial functions via the network of CaM-dependent proteins.