Background: Systemic intravenous antimicrobials yield poor outcomes during treatment of periprosthetic joint infection due to the inability to obtain minimum biofilm eradication concentrations. This study evaluated the safety of a novel method of optimized local delivery of intra-articular antibiotics (IAAs).
Methods: This was a Phase II, multicenter, prospective randomized trial evaluating safety of a rapid (seven-day) two-stage exchange arthroplasty with IAA irrigation compared to standard two-stage exchange.
J Arthroplasty
October 2013
Patient selection for cementless knee arthroplasty (TKA) remains challenging. 106 consecutive TKAs performed with a cementless porous tantalum tibial component of PS-design were reviewed. Nine failures (8 male/1 female) occurred at a mean 18 months and demonstrated a characteristic failure mode of medial tibial collapse.
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