A Randomized Crossover Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts.

Context: While increased fiber intake may benefit appetite and metabolism in the general population, its effects in individuals with Prader-Willi Syndrome (PWS), a condition characterized by hyperphagia, obesity and metabolic dysregulation, remain to be explored.

Objectives: This study assessed the effects of a fiber intervention on hyperphagia, metabolic health, and gut microbiota in individuals with PWS, and explored associations between changes in health markers and shifts in microbiota.

Methods: Participants received either a high-dose fiber intervention (35g/day) or a control for 3 weeks.