BRG1 (Brahma-Related Gene 1) Promotes Endothelial Transcription to Establish Embryonic Capillary Integrity.

Objective: The chromatin remodeling enzyme BRG1 (brahma-related gene 1) transcriptionally regulates target genes important for early blood vessel development and primitive hematopoiesis. However, because deletion in vascular progenitor cells results in lethal anemia by embryonic day 10.5 (E10.