A case report of cystoid macular edema, uveitis and vitreomacular traction in a patient taking Anastrozole.

Purpose: To report a case of cystoid macular edema, uveitis, and vitreomacular traction in a patient with a history of breast cancer and taking anastrozole.

Observations: A 73-year-old female with a history of estrogen receptor-positive breast cancer and treatment with anastrozole presented with bilateral blurry vision, photophobia, and eye soreness. Optical coherence tomography (OCT) of both maculae revealed vitreomacular traction (VMT), an epiretinal membrane, cystoid macular edema (CME) in the right eye, and drusen without subretinal fluid bilaterally Although later, macular OCT did show evidence of cystoid intraretinal spaces in the left eye as well.

Response to aflibercept after frequent re-treatment with bevacizumab or ranibizumab in eyes with neovascular AMD.

Background And Objective: To evaluate the effects of switching to aflibercept in eyes with neovascular age-related macular degeneration (AMD) requiring frequent re-treatment with bevacizumab or ranibizumab.

Patients And Methods: Retrospective review of 73 eyes of 65 patients with neovascular AMD switched to aflibercept due to persistent or recurrent macular fluid after at least 1 year of intravitreal bevacizumab or ranibizumab with re-treatment at least every 6 weeks. Minimum post-switch follow-up was 6 months.

Severe bilateral ischemic retinal vasculitis following cataract surgery.

This report describes two cases of severe, bilateral ischemic retinal vasculitis following cataract surgeries at different surgical centers. In both cases, the patient underwent bilateral cataract surgeries, performed 1 week apart for each eye. In the perioperative period following the second of the two surgeries, both patients developed severe, bilateral intraocular inflammation and profound vision loss.

Pseudocystic foveal cavitation in tamoxifen retinopathy.

Purpose: To present 3 cases of tamoxifen-induced foveal cavitation and review previous prospective and cross-sectional studies.

Design: Observational case series.

Methods: Retrospective analysis of patients presenting to a single institution with evidence of tamoxifen-induced maculopathy.

Epiretinal macular edema associated with thick epiretinal membranes.

High-resolution imaging with spectral-domain optical coherence tomography has identified an unusual group of epiretinal membranes (ERMs) in the presence of lamellar macular holes. These ERMs are unusually thick. The authors present the case of a patient with age-related macular degeneration who developed edema within a thickened ERM in both eyes after cataract surgery.

Initial outcomes following intravitreal ocriplasmin for treatment of symptomatic vitreomacular adhesion.

Background And Objective: When delivered via a single intravitreal injection, ocriplasmin can effect proteolytic resolution of symptomatic vitreomacular adhesion (VMA). The authors describe their initial clinical experience with ocriplasmin at a large academic center.

Patients And Methods: Retrospective review of all patients with symptomatic VMA treated with ocriplasmin from January 2013 through May 2013 at a single center.

The efficacy of a midfacial seal drape in reducing oculofacial surgical field fire risk.

Purpose: To evaluate the efficacy of a midface seal drape in eliminating fire risk oxygen concentrations from nasal cannulated oxygen delivery compared with a standard open oculofacial surgical field.

Methods: Controlled experiment using the SimMan patient simulator and an oxygen detector. Oxygen concentrations were measured at 9 facial surgical locations with nasal cannula flow rates of 2, 4, and 6 l/min of 100% FiO2 in both the draped and undraped conditions.

Amniotic membrane transplantation with anterior stromal micropuncture for treatment of painful bullous keratopathy in eyes with poor visual potential.

Purpose: To report the use of anterior stromal micropuncture and amniotic membrane transplantation in the management of painful bullous keratopathy in patients with poor visual potential.

Methods: Interventional case series. A retrospective review was performed to identify all patients who were treated by one of us (A.

No pathogenic mutations identified in the COL8A1 and COL8A2 genes in familial Fuchs corneal dystrophy.

Purpose: To investigate the genetic basis of late-onset, familial Fuchs endothelial corneal dystrophy (FECD) through screening of the COL8A1 and COL8A2 genes, in which mutations have been associated with both early and late-onset, familial and sporadic FECD.

Methods: DNA extraction, PCR amplification, and direct sequencing of the COL8A1 and COL8A2 genes was performed in affected and unaffected members of 15 unrelated families with two or more members with late-onset FECD.

Results: Screening of the COL8A1 gene did not reveal sequence variants in any affected individuals from the 15 FECD families.

Corneal copper deposition associated with chronic lymphocytic leukemia.

Purpose: To report a case of corneal copper deposition associated with chronic lymphocytic leukemia (CLL).

Design: Case report.

Methods: A 65-year-old woman with a history of CLL was diagnosed with bilateral corneal opacification.

Unilateral lattice corneal dystrophy associated with the novel His572del mutation in the TGFBI gene.

Purpose: To report a novel mutation in the TGFBI gene, c.1761_1763del (p.His572del), associated with a unilateral variant of lattice corneal dystrophy (LCD).

Clinical outcomes in patients with chronic congestive heart failure who undergo left ventricular assist device implantation.

Objective: The use of left ventricular assist devices as a bridge to transplantation for patients with chronic congestive heart failure is well accepted. However, few studies have examined outcomes solely for these patients. This study details one center's left ventricular assist device experience with this population.

Optimization of Schwann cell adhesion in response to shear stress in an in vitro model for peripheral nerve tissue engineering.

The design of nerve guidance channels (NGCs) is evolving to produce a favorable environment for neural regeneration. We created an in vitro model to evaluate the interactions between three centrally important components of this altered host environment: (1). Schwann cells, (2).