Publications by authors named "Brian Sze Ho Ho"

Background: Anticipating the postoperative pathological stage and potential for adverse features of prostate cancer (PCa) patients before radical prostatectomy (RP) is crucial for guiding perioperative treatment.

Methods: A cohort consisting of three sub-cohorts with a total of 709 patients has been enlisted from two major tertiary medical centres in China. The primary assessment parameters for adverse pathological features in this study are the pathological T stage, the AJCC prognostic stage groups and perineural invasion (PNI).

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Article Synopsis
  • Systematic prostate biopsies can lead to both overdiagnosis of less serious cancer and underdiagnosis of more serious cases; MRI-guided biopsies might offer better accuracy.
  • A study compared cancer detection rates between systematic biopsies and combined biopsies (systematic plus MRI-targeted) in Hong Kong men from 2015 to 2022, involving 1,391 participants.
  • While overall prostate cancer detection rates were similar (36.3% vs 36.6%), combined biopsies were better at identifying clinically significant cancer, particularly in men with PSA levels between 2-10 ng/ml, highlighting the potential benefits of MRI-targeted approaches.
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Background And Objective: Conventionally, standard resection (SR) is performed by resecting the bladder tumour in a piecemeal manner. En bloc resection of the bladder tumour (ERBT) has been proposed as an alternative technique in treating non-muscle-invasive bladder cancer (NMIBC). The objective of this study is to investigate whether ERBT could improve the 1-yr recurrence rate of NMIBC, as compared with SR.

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Background: The status of prostate-specific antigen (PSA) screening is unclear in China. Evidence regarding the optimal frequency and interval of serial screening for prostate cancer (PCa) is disputable.

Objective: This study aimed to depict the status of PSA screening and to explore the optimal screening frequency for PCa in China.

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We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance imaging. Men with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers (Queen Mary Hospital and Princess Margaret Hospital, Hong Kong, China) between January 2017 and June 2022 were included. Ultrasound-magnetic resonance imaging fusion biopsies were performed after prostate health index testing.

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Introduction: Pelvic hematomas are a rare complication of prostatic urethral lift. We would like to report the first case of massive pelvic hematoma after prostatic urethral lift that was successfully managed by selective angioembolization.

Case Presentation: An 83-year-old gentleman with benign prostatic hyperplasia underwent prostatic urethral lift.

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Objective: Early evidence is disputable for the effects of modifiable lifestyle behaviors on prostate cancer (PCa) risk. No research has yet appraised such causality in different ancestries using a Mendelian randomization (MR) approach.

Methods: A two-sample univariable and multivariable MR analysis was performed.

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Background And Objective: Urine culture is time consuming, which may take days to get the results and impede further timely treatment. Our objective is to evaluate whether the fast urinalysis and bacterial discrimination system called Sysmex UF-5000 may predict urinary tract infections (UTIs) (within minutes) compared with the clinical routine test in suspected UTI patients. In addition, we aimed to explore the accuracy of microbiologic information by UF-5000.

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Article Synopsis
  • A study analyzed the long-term survival outcomes of 782 Chinese prostate cancer patients who underwent radical prostatectomy (RP) from 1998 to 2022 at Queen Mary Hospital.
  • The 5-year, 10-year, and 15-year overall survival rates were reported as 96.6%, 86.8%, and 70.6%, while the prostate cancer-specific survival rates were 99.7%, 98.6%, and 97.8%, respectively.
  • Key findings indicated that higher Surgical ISUP grade (≥4) and factors like lymph node invasion and extracapsular extension correlated with poorer cancer-specific survival, but different surgical methods showed no significant differences in outcomes.
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Perineal hernia is a rare complication of anterior exenteration. We reported this complication after an anterior exenteration for bladder cancer with bleeding complication requiring packing and second-look laparotomy. Perineal approach is a simple and effective method for repair of perineal hernia.

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Penile fractures are an uncommon urological emergency. Typically, penile fractures involve the corpus cavernosum and are sometimes associated with urethral injury. Isolated corpus spongiosum and urethral injuries without concomitant corpus cavernosum injury are, however, rare.

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