Publications by authors named "Brian Sulkow"

During 2017 and 2018, we collected the quantity of questing black-legged ticks (), also known as deer ticks, in 124 sampling sites of 5m by 5m in four state parks-Caumsett State Historic Park, Connetquot River State Park, Rockefeller State Park, and Fire Island National Seashore-around New York City. The black-legged tick is the primary vector for the spirochete , the pathogen of Lyme disease, in Northeastern United States. Using the flagging method, we collected and counted the numbers of adult and nymphal black-legged ticks at each stie.

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Article Synopsis
  • Natural populations of pathogens and their hosts are in a constant evolutionary battle, complicating the creation of effective vaccines due to the pathogens' diverse antigenic profiles, specifically highlighted in Lyme Disease's outer surface protein C (OspC).
  • Researchers utilized a centroid algorithm to design synthetic OspC variants that minimize differences with natural versions, aiming to improve diagnostic and vaccine efficacy against multiple strains of the Lyme pathogen.
  • The study introduces the maximum antigen diversification model, proposing that these synthetic analogs can achieve broad cross-reactivity through a calculated approach, offering promising strategies to address challenges posed by evolving pathogens.
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The Standard Genetic Code (SGC) is robust to mutational errors such that frequently occurring mutations minimally alter the physio-chemistry of amino acids. The apparent correlation between the evolutionary distances among codons and the physio-chemical distances among their cognate amino acids suggests an early co-diversification between the codons and amino acids. Here we formulated the co-minimization of evolutionary distances between codons and physio-chemical distances between amino acids as a Traveling Salesman Problem (TSP) and solved it with a Hopfield neural network.

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