Publications by authors named "Brian Silverstrim"
Article Synopsis
- Chemotherapy is the main treatment for most cancers, but the effectiveness is often reduced due to drug resistance caused by ATP-binding cassette (ABC) transporters, which pump drugs out of cells.
- Researchers found that these transporters use mitochondria-derived ATP for energy and that a protein called MCJ helps regulate this process.
- By creating MCJ mimetics that lower mitochondrial respiration, they aim to enhance chemotherapy effectiveness and potentially improve treatment outcomes for cancer patients.
Development of metastasis in peripheral tissues is a major problem in the fight to cure breast cancer. Although it is becoming evident that chronic inflammation can contribute to tumor progression and metastasis, the effect of acute inflammation in primary tumor is less known. Using mouse models for breast cancer here we show that biopsy of mammary tumors increases the frequency of lung metastases.
View Article and Find Full Text PDFMitochondria are the main engine that generates ATP through oxidative phosphorylation within the respiratory chain. Mitochondrial respiration is regulated according to the metabolic needs of cells and can be modulated in response to metabolic changes. Little is known about the mechanisms that regulate this process.
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