Publications by authors named "Brian S Gruber"
Objective: In the past, the authors performed a comprehensive literature review to identify all randomized controlled trials assessing the impact of early tracheostomy on severe brain injury outcomes. The search produced only two trials, one by Sugerman and another by Bouderka.
Subjects And Methods: The current authors initiated an Institutional Review Board-approved severe brain injury randomized trial to evaluate the impact of early tracheostomy on ventilator-associated pneumonia rates, intensive care unit (ICU)/ventilator days, and hospital mortality.
Article Synopsis
- The study reassessed the relationship between end-tidal carbon dioxide (PetCO2) and cardiac output (CO) in trauma patients requiring emergency intubation, following earlier findings that suggested a positive correlation between the two.
- Data was collected from 73 acutely injured trauma patients over several months, revealing significant connections between low PetCO2 and low CO, particularly in those with signs of serious injury such as hypotension and major blood loss.
- The research concluded that low levels of PetCO2 are linked to clinical indicators of hemodynamic instability and increased mortality, affirming the clinical relevance of monitoring both metrics during emergency resuscitation.
Background: Anoninvasive cardiac output (CO) monitor (NICOM), using Bioreactance technology, has been validated in several nontrauma patient studies. We hypothesized that NICOM CO would have more significant associations with clinical conditions than would systolic blood pressure (sBP).
Methods: This is a prospective observational study of consecutive trauma activation patients during the first 10 to 60 minutes after emergency department arrival.
Introduction: The purpose of this study was to determine if noninvasive transcranial oxygen saturation (StcO2) and Bispectral Index (BIS) correlate with severe traumatic brain injury intensive care unit (ICU) outcomes.
Methods: This is a prospective observational study. Values of intracranial pressure (ICP), mean arterial pressure (MAP), BIS, and StcO2 were recorded hourly for the first six, post-injury days in 18 patients with severe brain injury.
Impaired wound healing is characteristic of diabetic patients. Potential reasons include poor inflammatory response, granulation tissue formation, and abnormal patterns of cytokine release and response. Vascular endothelial growth factor, abnormally regulated during healing in diabetics, is the major factor stimulating angiogenesis during normal wound healing.
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