Defining subgroups of patients with a stiff and painful shoulder: an analytical model using cluster analysis.

Purpose: The primary purpose of this research was to develop a classification system for patients with stiff and painful shoulders using hierarchical cluster analysis.

Methods: Medical charts of 52 patients treated for stiff and painful shoulders were reviewed for descriptive and clinical data after completion of their rehabilitation. A clinician-reported outcome was derived from ratings of three members of the American Society of Shoulder and Elbow Therapists.

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small molecules of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of protein active sites, allosteric binding sites, and protein-protein interaction surfaces for fragment binding.

Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy.

Proximal spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by death of motor neurons in the spinal cord that is caused by deletion and/or mutation of the survival motor neuron gene ( SMN1). Adjacent to SMN1 are a variable number of copies of the SMN2 gene. The two genes essentially differ by a single nucleotide, which causes the majority of the RNA transcripts from SMN2 to lack exon 7.