Publications by authors named "Brian O'Hara"

During the pandemic, there was an alarming escalation in reports of air rage in the United States. Prior to the pandemic, the yearly average of unruly airline passenger behaviors was around 100 incidents per year. However, after mask mandates were issued, 5981 unruly passenger incidents in the United States were reported by the Federal Aviation Administration (FAA) in 2021 alone.

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Objective: The present study aimed to determine the fidelity, reliability, and internal validity of the APDQ when translated from English to Brazilian-Portuguese language.

Methods: The first phase included the APDQ translation into Brazilian-Portuguese including forward translation, translation assessment and back-translation in a group of 10 students. The second phase involved establishing the internal consistency and reliability of the APDQ Brazilian-Portuguese version.

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Strongyloidiasis is an intestinal infection caused by the nematode , and it is rarely seen in our clinical practice in the United States. Although it remains localized to the gastrointestinal tract most of the time, it can disseminate to other organs when it causes autoinfection in the setting of immunosuppression. The clinical manifestations vary depending on the involved organ.

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Age-related tendon degeneration (tendinosis) is characterized by a phenotypic change in which tenocytes display characteristics of fibrochondrocytes and mineralized fibrochondrocytes. As tendon degeneration has been noted in vivo in areas of decreased tendon vascularity, we hypothesized that hypoxia is responsible for the development of the tendinosis phenotype, and that these effects are more pronounced in aged tenocytes. Hypoxic (1% O ) culture of aged, tendinotic, and young human tenocytes resulted in a mineralized fibrochondrocyte phenotype in aged tenocytes, and a fibrochondrocyte phenotype in young and tendinotic tenocytes.

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Objective: The aim of this study was to develop a screening questionnaire for auditory processing disorder (APD).

Design: Fifty-two questions were created to enable parent/teacher proxies to rate students listening skills in terms of auditory processing, attention and language factors.

Study Sample: Parents rated their child's frequency of competent performance (regularly, often, sometimes or rarely) on 52 questions.

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Fibrous pseudotumors are rare benign lesions that originate within the paratesticular tissues. Local excision is the preferred method of treatment of these tumors over radical orchiectomy, however a definitive diagnosis must be made beforehand given the similarity of these tumors to malignant entities. We present a case of fibrous pseudotumor of the tunica vaginalis and cauda epididymis.

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Article Synopsis
  • Increasing use of ventricular-assist devices (VADs) for heart failure has led to research on less invasive implantation methods, particularly comparing minimally invasive left thoracotomy (LT) to conventional sternotomy (CS).
  • This study reviewed data from 81 patients who underwent HVAD implantation using either technique, focusing on perioperative outcomes and 6-month postoperative events.
  • Results indicated that while the LT approach required fewer transfusions, there were no significant differences in morbidity or mortality between the two groups at 6 months, suggesting comparable safety and outcomes for both methods.
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Background: There is a growing recognition that environmental design impacts health and well-being. Nature contact is a design feature or exposure that is especially important in public health and healthcare. To date, there are limited findings on the impact of nature sounds.

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Objectives/hypothesis: To evaluate the potential for injectable, permanent bone augmentation by assessing the biocompatability and bioactivity of subperiosteal hydroxylapatite (Radiesse) deposition in a rat model.

Study Design: Randomized controlled animal model.

Methods: Fourteen adult Sprague Dawley rats were injected in the parietal skull with 0.

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Cholangiocarcinoma is a rare disease with a reported incidence in the United States of 1 to 2 cases per 100,000 population. These cancers have a high mortality rate because most are locally advanced at presentation. Cholangiocarcinoma most commonly advances locally and regionally by invading the lymph nodes.

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Objective: To determine the frequency and clinical relevance of unanticipated histopathologic results in routine sinonasal surgery and evaluate the necessity for histologic processing of nasal septal cartilage, bone, and inferior turbinate specimens.

Study Design: Case series with chart review.

Setting: Tertiary care academic medical center.

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Background: Minimally invasive thyroidectomy (MIT) has gained popularity in the surgical management of benign and malignant pathology of the thyroid. One of the main benefits of utilizing this technique is the use of smaller incisions resulting in increased cosmetic satisfaction. Unfortunately, the retraction required for adequate exposure during MIT may lead to skin damage, impaired wound healing and poor cosmetic outcomes.

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Most cases of primary hyperparathyroidism (80 to 90%) are caused by a parathyroid adenoma; most of the rest are caused by either parathyroid gland hyperplasia or multiple adenomas. Parathyroid carcinoma can be the cause of primary hyperparathyroidism in 1 to 5% of patients. When the appropriate clinical scenario is presented, it must be considered in the differential diagnosis.

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Small non-coding microRNAs (miRNAs) contribute to cancer development and progression, and are differentially expressed in normal tissues and cancers. However, the specific role of miRNAs in the metastatic process is still unknown. To seek a specific miRNA expression signature characterizing the metastatic phenotype of solid tumours, we performed a miRNA microarray analysis on 43 paired primary tumours (ten colon, ten bladder, 13 breast, and ten lung cancers) and one of their related metastatic lymph nodes.

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Background: We conducted a prospective, controlled, blinded pilot study to demonstrate that repair of induced rabbit orbital floor fractures with Surgisis ES (Cook Biotech Inc, West Lafayette, Ind) provides adequate orbital content support while promoting mucosal and bone regeneration of the fracture site.

Material/methods: Ten New Zealand white rabbits underwent induced bilateral controlled (5mm) orbital floor fractures under anesthesia. In each rabbit, Surgisis ES, an acellular, freeze-dried soft tissue matrix derived from porcine small intestinal submucosa, was implanted subperiosteally to repair one orbital floor fracture through a transconjuntival approach.

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Background: Idiopathic granulomatous mastitis is an uncommon, benign entity with a diagnosis of exclusion. The typical clinical presentation of idiopathic granulomatous mastitis often mimics infection or malignancy. As a result, histopathological confirmation of idiopathic granulomatous mastitis combined with exclusion of infection, malignancy and other causes of granulomatous disease is absolutely necessary.

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Objectives/hypothesis: The objective was to demonstrate that interpositional grafting with porcine small intestinal submucosa promotes cartilage regeneration following excision of rabbit auricular cartilage.

Study Design: Blinded, controlled study.

Methods: Eight New Zealand white rabbits underwent excision of auricular cartilage on two sites with and two sites without preservation of perichondrium.

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Objectives/hypothesis: To delineate the clinical and pathologic characteristics of upper aerodigestive tract amyloidosis with particular attention to laryngeal amyloidosis.

Study Design: Retrospective chart review of patients with amyloidosis of Thomas Jefferson University and its affiliated hospitals.

Material And Methods: The charts of 16 patients with upper aerodigestive tract amyloidosis identified from the databases of the Thomas Jefferson University pathology department were reviewed and included in the study.

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Rationale And Objectives: The purpose of this study was to determine whether adrenal cortical lipid affects signal intensity on magnetic resonance (MR) images and to evaluate contrast between cortex and medulla.

Materials And Methods: From their clinical database, the authors selected 37 MR imaging studies of patients with adrenal adenomas. Two independent readers compared in-phase and fat-suppressed T1-weighted images, looking for visible lipid-induced signal intensity loss in the adrenal gland.

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