Publications by authors named "Brian N Bourke"
Article Synopsis
- The study investigates the role of matrix metalloproteinases (MMPs) in adverse left ventricular remodeling after myocardial infarction (MI) and emphasizes the need for noninvasive monitoring methods.
- Researchers developed MMP-targeted radiotracers that bind selectively to active MMPs, showing significant retention in MI areas through both initial nonimaging studies and further imaging techniques.
- The findings suggest that the novel imaging approach can effectively track MMP activation and its effects in heart tissue, providing diagnostic benefits for monitoring post-MI remodeling.
Background: Noninvasive imaging strategies play a critical role in assessment of the efficacy of angiogenesis therapies. The alpha(v)beta3 integrin is activated in angiogenic vessels and represents a potential target for noninvasive imaging of angiogenesis.
Methods And Results: We evaluated a 99mTc-labeled peptide (NC100692) targeted at alpha(v)beta3 integrin for imaging in an established murine model of angiogenesis induced by hindlimb ischemia.
Noninvasive imaging strategies will be critical for defining the temporal characteristics of angiogenesis and assessing efficacy of angiogenic therapies. The alphavbeta3 integrin is expressed in angiogenic vessels and represents a potential novel target for imaging myocardial angiogenesis. We demonstrated the localization of an indium-111-labeled ((111)In-labeled) alphavbeta3-targeted agent in the region of injury-induced angiogenesis in a chronic rat model of infarction.
View Article and Find Full Text PDF