Perspective: A Novel Prognostic for Sickle Cell Disease.

Sickle hemoglobin (αβ ) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (αγ) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-making relies on diagnostic technologies evaluating fetal hemoglobin as mean percent or mean quantity in blood.