Publications by authors named "Brian M McEllin"
Clin Cancer Res
January 2010
Article Synopsis
- - Imetelstat, a novel telomerase antagonist, shows potential as a therapeutic target for glioblastoma (GBM) by inhibiting telomerase activity, leading to cell death and reduced proliferation in tumor-initiating cells.
- - The study found that long-term imetelstat treatment caused significant telomere shortening and enhanced the effectiveness when combined with radiation and the chemotherapy drug temozolomide, activating the DNA damage response.
- - Results demonstrated that imetelstat can cross the blood-brain barrier, effectively reducing tumor growth in mouse models, suggesting its feasibility for future clinical trials in GBM patients, either alone or with standard treatments.
