Publications by authors named "Brian Kirshon"
We analyzed maternal plasma cell-free DNA samples from twin pregnancies in a prospective blinded study to validate a single-nucleotide polymorphism (SNP)-based non-invasive prenatal test (NIPT) for zygosity, fetal sex, and aneuploidy. Zygosity was evaluated by looking for either one or two fetal genome complements, fetal sex was evaluated by evaluating Y-chromosome loci, and aneuploidy was assessed through SNP ratios. Zygosity was correctly predicted in 100% of cases (93/93; 95% confidence interval (CI) 96.
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- High-order multiple pregnancies (four or more fetuses) pose significant risks, especially extreme prematurity.
- Interval delivery techniques were successfully applied in cases of octuplet, sextuplet, and quadruplet pregnancies, with varying delivery intervals.
- It is advisable to consider delayed interval delivery in high-order multiple pregnancies, as long as there are no severe complications like infections or fetal/maternal distress.