Publications by authors named "Brian Kirby"
Article Synopsis
- - The EXACT trial, sponsored by the National Cancer Institute, aims to evaluate whether 150 minutes of weekly moderate-intensity aerobic exercise can lower systemic inflammation in stage I-III colorectal cancer survivors compared to a control group over 12 weeks.
- - Recruitment for the study involved inviting over 3,000 survivors, with 89 screened and 60 randomized, revealing that younger age, female sex, and certain racial and clinical factors positively influenced participation.
- - Findings showed high exercise adherence at 92.2%, with all participants meeting the 80% adherence goal, and the trial will provide insights into how exercise may help prevent cancer recurrence and improve survival rates.
Mild psoriasis may be burdensome; if symptoms are inadequately controlled, switching therapy may be warranted. In the Phase 3 NAVIGATE trial, patients with moderate-to-severe plaque psoriasis received ustekinumab for 16 weeks. Patients with inadequate response (Investigator's Global Assessment [IGA] ≥ 2) were randomized to switch to guselkumab or continue ustekinumab.
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- Hidradenitis suppurativa (HS) is linked to higher cardiovascular disease risk, and biomarkers like SII, NLR, PLR, and MLR indicate systemic inflammation and CVD.
- A study aimed to observe these biomarkers in a larger group of HS patients undergoing treatment with adalimumab and evaluate their relationship with disease severity and treatment outcomes.
- Results showed that adalimumab significantly reduced these inflammatory biomarkers after 12 weeks, indicating a sustained response, while placebo patients saw no change; correlations with the severity of the disease were also noted.
Article Synopsis
- - Psoriasis (PsO) is categorized as mild, moderate, or severe primarily based on body surface area (BSA), and mild cases typically receive topical treatments; however, there's debate over when to use biologics as first-line options even for mild cases.
- - At the GRAPPA 2023 meeting, proponents of biologics highlighted cases like psoriatic arthritis (PsA) and significant symptoms on sensitive areas (such as the scalp or genitals) as reasons to consider biologic therapy for mild PsO.
- - Critics argue that true mild PsO shouldn't include patients with PsA or major quality of life issues, advocating instead for topical treatments that are safer and more cost-effective, especially with newer options
Methods for describing and reporting the clinical and histologic characteristics of cutaneous tissue samples from patients with hidradenitis suppurativa (HS) are not currently standardized, limiting clinicians' and scientists' ability to uniformly record, report, and communicate about the characteristics of tissue used in translational experiments. A recently published consensus statement outlined morphological definitions of typical HS lesions, but no consensus has been reached regarding clinical characterization and examination of HS tissue samples. In this study, we aimed to establish a protocol for reporting histopathologic and clinical characteristics of HS tissue specimens.
View Article and Find Full Text PDFPurpose Of Review: Topical therapies are a mainstay of treatment for mild psoriasis and may be a useful adjunct in treatment of moderate-to-severe psoriasis. This review summarizes recent advances in topical therapies for psoriasis and currently available treatments.
Recent Findings: Topical aryl hydrocarbon receptor modulators (tapinarof) and topical phosphodiesterase-4 inhibitors (roflumilast) have been proven effective in randomized controlled trials for psoriasis.
The effect of oxygen reduction on the magnetic properties of LaFeO (LFO) thin films was studied to better understand the viability of LFO as a candidate for magnetoionic memory. Differences in the amount of oxygen lost by LFO and its magnetic behavior were observed in nominally identical LFO films grown on substrates prepared using different common methods. In an LFO film grown on SrTiO (STO) substrate, the original perovskite film structure was preserved following reduction, and remnant magnetization was only seen at low temperatures.
View Article and Find Full Text PDFOur goal was to determine the impact of physiological and pathological shear histories on platelet nucleation and thrombus growth at various local shear rates. We designed and characterized a microfluidic device capable of subjecting platelets to shear histories reaching as high as 6700 s in a single passage. Time-lapse videos of platelets and thrombi are captured using fluorescence microscopy.
View Article and Find Full Text PDFThe blood-brain barrier (BBB) is a complex, dynamic, and adaptable barrier between the peripheral blood system and the central nervous system. While this barrier protects the brain and spinal cord from inflammation and infection, it prevents most drugs from reaching the brain tissue. With the expanding interest in the pathophysiology of BBB, the development of BBB models has dramatically evolved.
View Article and Find Full Text PDFBackground: Hidradenitis suppurativa (HS) is associated with lower socioeconomic status (SES). The adverse influence of HS on education and employment may explain this. It remains unknown whether HS causes downward social trajectories, i.
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- There are existing registries for hidradenitis suppurativa (HS) in Europe and the USA, but there is no global standard on the data collected, which complicates international collaboration.
- The goal is to create a core dataset (CDS) for global HS registries covering demographics, comorbidities, clinical findings, patient outcomes, and treatments.
- A Delphi process involving 20 experts from eight countries resulted in a consensus on 48 items to be included in all HS registries, promoting consistent data collection worldwide.
The fact that quantum mechanics predicts stronger correlations than classical physics is an essential cornerstone of quantum information processing. Indeed, these quantum correlations are a valuable resource for various tasks, such as quantum key distribution or quantum teleportation, but characterizing these correlations in an experimental setting is a formidable task, especially in scenarios where no shared reference frames are available. By definition, quantum correlations are reference-frame independent, i.
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- - Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting about 1-2% of the population, though it’s likely underreported due to various factors including diagnosis challenges and data collection differences.
- - The condition leads to painful nodules and abscesses mostly in areas like the armpits and groin; chronic inflammation can cause severe tissue damage and scarring over time.
- - Current treatments range from topical and systemic medications to surgical options, with adalimumab being the only FDA-approved biologic, but it works in only about half of patients; ongoing research explores new therapies targeting various pathways for better outcomes.
Background: Targeting immunometabolism has shown promise in treating autoimmune and inflammatory conditions. Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease involving painful lesions in apocrine gland-bearing skin. Therapeutic options for HS are limited and often ineffective; thus, there is a pressing need for improved treatments.
View Article and Find Full Text PDFThe magnetic properties of permalloy-based trilayers of the form PyCu/PyCu/Py/IrMn were studied as the spacer layer undergoes a paramagnetic to ferromagnetic phase transition. We find the coupling between the free PyCu layer and the exchange bias pinned Py to be strongly temperature-dependent: there is negligible coupling above the Curie temperature of the PyCu spacer layer, strong ferromagnetic coupling below that temperature, and a tunable coupling between these extremes. Polarized neutron reflectometry was used to measure the depth profile of the magnetic order in the system, allowing us to correlate the order parameter with the coupling strength.
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- * A study of 34 patients on biologic therapy revealed a concerning average delay of 12.4 years from diagnosis to treatment initiation, despite some shorter waiting times from clinic visits to treatment.
- * To improve outcomes, the study emphasizes the need to enhance early diagnosis and facilitate quicker access to specialized HS care and biologic treatments.
Background: Treatment for the debilitating disease hidradenitis suppurativa (HS) is inadequate in many patients. Despite an incidence of approximately 1%, HS is often under-recognized and underdiagnosed, and is associated with a high morbidity and poor quality of life.
Objectives: To gain a better understanding of the pathogenesis of HS, in order to design new therapeutic strategies.
Hidradenitis suppurativa (HS) is a common cutaneous and systemic inflammatory disease with a significant impact on mental health and quality of life. It is associated with obesity, insulin resistance, metabolic syndrome, cardiovascular (CV) disease, and increased all-cause mortality. Metformin is used frequently in HS treatment and is effective for some patients.
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