Comparison of Cerebral Palsy Severity Between 2 Eras of Antenatal Magnesium Use.

This before-and-after cohort analysis assesses whether implementing a recommendation of antenatal magnesium use at an institutional level in 2009 resulted in fewer subsequent cases of moderate or severe cerebral palsy.

Management of a rapidly enlarging new adnexal mass: a rare case of desmoplastic small round cell tumor of the ovary arising in pregnancy.

Background: Desmoplastic small round cell tumor (DSRCT) is an extremely rare sarcomatous tumor, which is most commonly seen in men. Clinicians managing a patient with a rapidly enlarging mass in pregnancy should be aware of the risk for malignancy.

Case: A 31-year-old woman was found to have a newly enlarged ovarian mass in the second trimester.

Diffuse intra-abdominal splenosis presenting as carcinomatosis exhibiting positron emitted tomography hypermetabolic activity.

•Splenosis can mimic carcinomatosis upon many imaging modalities.•History of splenectomy must be considered when evaluating carcinomatosis.•Scintigraphy is the preferred for confirming the presence of splenosis.

Estrogen rapidly attenuates cannabinoid-induced changes in energy homeostasis.

We examined whether estrogen negatively modulates cannabinoid-induced regulation of food intake, core body temperature and neurotransmission at proopiomelanocortin (POMC) synapses. Food intake was evaluated in ovariectomized female guinea pigs abdominally implanted with thermal DataLoggers and treated s.c.

A new model of neonatal stress which produces lasting neurobehavioral effects in adult rats.

Background: During critical care in neonatal intensive care units (NICU), infants experience stressors and treatments that may produce lasting effects on adult health. An animal model simulating the NICU experience is needed to understand the impact of specific neonatal stressors.

Objective: We combined approaches to develop a neonatal rat model simulating NICU stressors in order to examine the hypothesis that early stress and morphine sulfate (MS) exposure would affect development and alter adult behavior.

A comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal rats.

Recombinant human erythropoietin (rEpo) is neuroprotective in neonatal models of hypoxic-ischemic brain injury. However, the optimal rEpo dose, dosing interval, and number of doses for reducing brain injury are still undetermined. We compared the neuroprotective efficacy of several subcutaneous rEpo treatment regimens.

Pharmacokinetics of high-dose recombinant erythropoietin in plasma and brain of neonatal rats.

Recombinant human erythropoietin (rEpo) is neuroprotective in neonatal models of brain injury. Pharmacokinetic data regarding the penetration of circulating rEpo into brain tissue is needed to optimize neuroprotective strategies. We sought to determine the pharmacokinetics of rEpo given intraperitoneally or subcutaneously in plasma and brain.