Activity of novel antibiotic lock solutions in a model against isolates of catheter-related bloodstream infections.

Background: Catheter-related bloodstream infections (CRBSIs) are a primary concern in patients with indwelling central venous catheters (CVCs). Instillation of an antibiotic lock solution may serve as an adjunctive therapy.

Objective: To evaluate the efficacy of novel antibiotic-anticoagulant lock solutions using an in vitro model of CVC infection.