Publications by authors named "Brian Jonat"
Background And Objectives: Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory illness occurring after severe acute respiratory syndrome coronavirus 2 infection. The optimal treatment of MIS-C is unknown, although prior studies have indicated benefits of intravenous immunoglobulin (IVIG) and glucocorticoids. We hypothesize that early treatment with glucocorticoids is associated with shorter hospital length of stay (LOS).
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- * A multidisciplinary team created the protocol based on extensive literature and hands-on experience, aiming to enhance case identification, risk stratification, and treatment approaches for children with MIS-C.
- * The implemented protocol successfully treated 54 patients over two months, with all patients surviving without requiring invasive support, demonstrating improved early treatment outcomes and effective follow-up care.
Antimalarial drug resistance in the parasite poses a constant challenge for drug development. To mitigate this risk, new antimalarial medicines should be developed as fixed-dose combinations. Assessing the pharmacodynamic interactions of potential antimalarial drug combination partners during early phases of development is essential in developing the targeted parasitological and clinical profile of the final drug product.
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