Publications by authors named "Brian James Murray"

Sleep has important clinical implications for neurorehabilitation after stroke. We aimed to systematically explore sleep (including naps) as an essential factor in the neurorehabilitation of patients after stroke. After titles and abstracts were screened, 49 full texts were reviewed, and 7 were included in this review.

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This article describes clinical approaches to assessing sleepiness. Subjective sleep scales are used in clinical settings but have significant limitations. Likewise, objective tools may have prohibitive expense, and practical administration considerations may prohibit regular use.

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This article describes clinical approaches to assessing sleepiness. Subjective sleep scales are used in clinical settings but have significant limitations. Likewise, objective tools may have prohibitive expense, and practical administration considerations may prohibit regular use.

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Sleep is characterized by changes in neural firing and chemistry compared with wakefulness. Many neurologic diseases affect pathways that regulate control of sleep state and some primary sleep disorders have abnormalities of this circuitry. Nonrapid eye movement (NREM) and rapid eye movement (REM) sleep alternate in an approximately 90-minute cycle.

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Article Synopsis
  • - Recent research suggests narcolepsy may be linked to autoimmune issues, but the specific role of CD40L hasn't been studied until now.
  • - This study measured levels of CD40L, various lymphocyte types, and key inflammatory markers (tumor necrosis factor-α and interleukin-6) in narcoleptic patients compared to control subjects.
  • - Results showed narcoleptic patients had lower levels of CD40L and total lymphocytes, particularly CD3 and TCD4, indicating that CD40L plays a significant role in the condition.
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