Two TonB systems in Actinobacillus pleuropneumoniae: their roles in iron acquisition and virulence.

Iron acquisition in vivo by Actinobacillus pleuropneumoniae depends upon a functional TonB system. Tonpitak et al. (W.

Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host.

Actinobacillus pleuropneumoniae is a strict respiratory tract pathogen of swine and is the causative agent of porcine pleuropneumonia. We have used signature-tagged mutagenesis (STM) to identify genes required for survival of the organism within the pig. A total of 2,064 signature-tagged Tn10 transposon mutants were assembled into pools of 48 each, and used to inoculate pigs by the endotracheal route.

Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection.

Actinobacillus pleuropneumoniae causes porcine pleuropneumonia, a highly contagious disease for which there is no effective vaccine. This review considers how adhesins, iron-acquisition factors, capsule and lipopolysaccharide, RTX cytotoxins and other potential future vaccine components contribute to colonisation, to avoidance of host clearance mechanisms and to damage of host tissues.

Active copper- and zinc-containing superoxide dismutase in the cryptic genospecies of Haemophilus causing urogenital and neonatal infections discriminates them from Haemophilus influenzae sensu stricto.

The presence of active copper- and zinc-containing superoxide dismutase in isolates of the cryptic genospecies of Haemophilus, responsible for urogenital, neonatal, and mother-infant infections, can be used as a biochemical marker to discriminate them from H. influenzae sensu stricto strains.