Association of social determinants of health with first antiseizure medication prescription for patients with newly diagnosed epilepsy: A systematic review and meta-analysis.

Objective: To assess whether social determinants of health (SDOHs) are associated with the first antiseizure medication (ASM) prescribed for newly diagnosed epilepsy.

Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards were followed, and the protocol registered (CRD42023448998). Embase, Medline, and Web of Science were searched up to July 31, 2023.

Outcomes of Immunotherapy Treatment in Sinonasal Mucosal Melanoma.

Background: Sinonasal mucosal melanoma has poor survival despite multimodality treatment. While the impact of immunotherapy (IT) on metastatic cutaneous melanoma is well-defined, there are relatively little data on sinonasal mucosal melanoma.

Objective: We sought to define immunotherapy outcomes in patients with sinonasal mucosal melanoma.

Automated differentiation of mixed populations of free-flying female mosquitoes under semi-field conditions.

Great advances in automated identification systems, or 'smart traps', that differentiate insect species have been made in recent years, yet demonstrations of field-ready devices under free-flight conditions remain rare. Here, we describe the results of mixed-species identification of female mosquitoes using an advanced optoacoustic smart trap design under free-flying conditions. Point-of-capture classification was assessed using mixed populations of congeneric (Aedes albopictus and Aedes aegypti) and non-congeneric (Ae.

A decision support tool for risk-benefit analysis of Japanese encephalitis vaccine in travellers.

Background: During pre-travel consultations, clinicians and travellers face the challenge of weighing the risks verus benefits of Japanese encephalitis (JE) vaccination due to the high cost of the vaccine, low incidence in travellers (~1 in 1 million), but potentially severe consequences (~30% case-fatality rate). Personalised JE risk assessment based on the travellers' demographics and travel itinerary is challenging using standard risk matrices. We developed an interactive digital tool to estimate risks of JE infection and severe health outcomes under different scenarios to facilitate shared decision-making between clinicians and travellers.

Joint FAO/IAEA Coordinated Research Project on "" in Support of SIT Application to Control Mosquitoes.

Mosquito-borne diseases are among the most important public health problems worldwide [...

Sinonasal Mucosal Melanoma: Role of Tumor Proliferative Indices and Pathological Factors in Survival.

Objective: The objective of this study is to determine the association of proliferation indices and pathologic biomarkers on overall and recurrence/metastasis-free survival (OS and RMFS) in patients with sinonasal mucosal melanoma (SNMM) and to assess the genetic mutational landscape of SNMM.

Methods: This is a retrospective cohort study of 45 SNMM patients without neoadjuvant therapy who underwent surgical therapy with curative intent and had tumor tissue available for histopathologic review, molecular analysis, and genetic mutational assessment. The OS and RMFS were assessed for associations with numerous tumor and patient-related factors.

Modifications to Implanting the OSIA® 2 Bone Conduction Hearing Implant: How I Do it.

This "How I Do It" report describes modifications made to the OSIA bone conduction hearing implant surgery in order to reduce wound complications. Laryngoscope, 132:1850-1854, 2022.

The Use of Automated Traps to Assess the Efficacy of Insecticide Barrier Treatments Against Abundant Mosquitoes in Remote Environments.

Commercially available 'smart' trap technology has not yet been widely used to evaluate interventions against mosquitoes despite potential benefits. These benefits include the ability to capture data continuously at fine temporal scales without the human resources usually required for conventional trap deployment. Here, we used a commercially available smart trap (BG-Counter, Biogents) to assess the efficacy of an insecticide barrier treatment (BiFlex AquaMax) in reducing mosquito nuisance in a logistically challenging coastal environment in Queensland, Australia.

Mark-release-recapture of male Aedes aegypti (Diptera: Culicidae): Use of rhodamine B to estimate movement, mating and population parameters in preparation for an incompatible male program.

Rapid advances in biological and digital support systems are revolutionizing the population control of invasive disease vectors such as Aedes aegypti. Methods such as the sterile and incompatible insect techniques (SIT/IIT) rely on modified males to seek out and successfully mate with females, and in doing so outcompete the wild male population for mates. Currently, these interventions most frequently infer mating success through area-wide population surveillance and estimates of mating competitiveness are rare.

The environmental and ecological determinants of elevated Ross River Virus exposure in koalas residing in urban coastal landscapes.

Koala populations in many areas of Australia have declined sharply in response to habitat loss, disease and the effects of climate change. Koalas may face further morbidity from endemic mosquito-borne viruses, but the impact of such viruses is currently unknown. Few seroprevalence studies in the wild exist and little is known of the determinants of exposure.

Further Evidence that Development and Buffer Zones Do Little To Reduce Mosquito Nuisance from Neighboring Habitat.

Little is known regarding the comparative source-sink relationships between primary mosquito breeding sites (source) and neighboring (sink) environments in heterogeneous landscapes. An exploration of those relationships may provide unique insights into the utility of open-space buffer zone mitigation strategies currently being considered by urban planners to reduce contact between mosquitoes and humans. We investigated the source-sink relationships between a highly productive mosquito habitat and adjacent residential (developed) and rural (undeveloped) coastal environments.

Mosquito-Borne Viruses and Non-Human Vertebrates in Australia: A Review.

Mosquito-borne viruses are well recognized as a global public health burden amongst humans, but the effects on non-human vertebrates is rarely reported. Australia, houses a number of endemic mosquito-borne viruses, such as Ross River virus, Barmah Forest virus, and Murray Valley encephalitis virus. In this review, we synthesize the current state of mosquito-borne viruses impacting non-human vertebrates in Australia, including diseases that could be introduced due to local mosquito distribution.

The presence of knockdown resistance mutations reduces male mating competitiveness in the major arbovirus vector, Aedes aegypti.

Background: The development of insecticide resistance in mosquitoes can have pleiotropic effects on key behaviours such as mating competition and host-location. Documenting these effects is crucial for understanding the dynamics and costs of insecticide resistance and may give researchers an evidence base for promoting vector control programs that aim to restore or conserve insecticide susceptibility.

Methods And Findings: We evaluated changes in behaviour in a backcrossed strain of Aedes aegypti, homozygous for two knockdown resistance (kdr) mutations (V1016G and S989P) isolated in an otherwise fully susceptible genetic background.

Chronic rhinosinusitis in patients with cystic fibrosis-Current management and new treatments.

Objectives: The purpose of this article is to provide a state-of-the-art review of the literature and summarize the latest publications on medical and surgical treatment of cystic fibrosis (CF) chronic rhinosinusitis (CRS), with an emphasis on describing recent advancements in cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies.

Methods: A comprehensive literature review was conducted utilizing the PubMed database with search phrases detailed within the body of the article. Abstracts were reviewed to include publications detailing medical, surgical, and CFTR modulating therapies for CF CRS.

Performance of an aerially applied liquid Bacillus thuringiensis var. israelensis formulation (strain AM65-52) against mosquitoes in mixed saltmarsh-mangrove systems and fine-scale mapping of mangrove canopy cover using affordable drone-based imagery.

Background: In the Australian southeast, the saltmarsh mosquito Aedes vigilax (Skuse) is the focus of area-wide larviciding campaigns employing the biological agent Bacillus thuringiensis var. israelensis (Bti). Although generally effective, frequent inundating tides and considerable mangrove cover can make control challenging.

Mosquito Age Grading and Vector-Control Programmes.

An ability to characterize the age of mosquito populations could provide cost-effective and compelling entomological evidence for the potential epidemiological impacts of vector control. The average age of a mosquito population is the most important determinant of vectorial capacity and the likelihood of disease transmission. Yet, despite decades of research, defining the age of a wild-caught mosquito remains a challenging, impractical, and unreliable process.

A Novel Methodology For Recording Wing Beat Frequencies of Untethered Male and Female .

is a vector of many significant arboviruses worldwide, including dengue, Zika, chikungunya, and yellow fever viruses. With vector control methodology pivoting toward rearing and releasing large numbers of insects for either population suppression or virus-blocking, economical remote (sentinel) surveillance methods for release tracking become increasingly necessary. Recent steps in this direction include advances in optical sensors that identify and classify insects based on their wing beat frequency (WBF).

Neighbors help neighbors control urban mosquitoes.

The worldwide spread of invasive Aedes mosquitoes and arboviral disease, have renewed the pressure for effective and sustainable urban mosquito control. We report on the success of a model we are confident will usher in a new era of urban mosquito control. The key innovation is the mobilization of neighbors guided by scientific advisors, an approach we termed Citizen Action through Science (Citizen AcTS).

A low-cost, battery-powered acoustic trap for surveilling male Aedes aegypti during rear-and-release operations.

The Aedes aegypti mosquito is a primary vector of several serious arboviruses throughout the world and is therefore of great concern to many public health organizations. With vector control methodology pivoting towards rearing and releasing large numbers of genetically modified, sterilized, or Wolbachia-infected male mosquitoes to control vector populations, economical surveillance methods for release tracking becomes increasingly necessary. Previous work has identified that male Ae.