Publications by authors named "Brian J H Lee"
Article Synopsis
- - Dye-based angiography is widely used to examine blood vessels in the eye, especially in the retina, but it has limitations due to being invasive and time-consuming.
- - Anterior segment optical coherence tomography angiography (AS-OCTA) is a non-invasive alternative that creates high-resolution images of the cornea and ocular surface, effectively visualizing blood vessels.
- - AS-OCTA is beneficial for various clinical applications, including assessing corneal neovascularization, diagnosing ocular surface squamous neoplasia, and evaluating conditions like limbal stem cell deficiency and ischemia.
Purpose: To describe an approach using sequential excimer laser ablation of the stromal surface of the corneal flap with or without subsequent excimer ablation to the stromal bed to reduce presbyopic inlay-associated corneal haze.
Methods: Twelve patients who underwent KAMRA inlay (Acufocus) explantation due to corneal haze were included. The mean interval between explantation and the primary surgery (phototherapeutic keratotomy [PTK] to corneal flap) was 16.
Purpose: The study aimed to describe the phenotypic features of retinitis pigmentosa (RP) associated with the previously described EYS C2139Y variant in Singaporeans and establish the importance of this variant as a prevalent cause of RP among East Asians.
Methods: A clinical phenotyping and exome-sequencing study was conducted on consecutive patients with nonsyndromic RP. Epidemiological analysis was performed using Singaporean and global population-based genetic data.
Objective: To assess the economic impact of inherited retinal disease (IRD) among Singaporeans.
Methods: IRD prevalence was calculated using population-based data. Focused surveys were conducted for sequentially enrolled IRD patients from a tertiary hospital.
Background: Ongoing trials for retinitis pigmentosa (RP) are genotype-specific, with most trials conducted on European cohorts. Due to genetic differences across diverse ancestries and populations, these therapies may not be efficacious in East Asians.
Materials And Methods: A literature search was conducted from 1966 to September 2022 for cohort studies on East Asian populations reporting on non-syndromic RP genotypes and variants.
Gallstones are a common public health problem, especially in developed countries. There are an increasing number of patients who are diagnosed with gallstones due to increasing awareness and liberal use of imaging, with 22.6%-80% of gallstone patients being asymptomatic at the time of diagnosis.
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