Publications by authors named "Brian Hollenbeck"

Debridement with antibiotics and implant retention (DAIR) is commonly utilized for prosthetic joint infection (PJI) for total knee arthroplasty (TKA); particularly in cases of acute PJI 1. Reported success rates of DAIR have been highly variable, but the overall success rate of DAIR cohort studies is ~70-80% 2. However, no large database studies have investigated the success rate of DAIR.

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Injections are a common preoperative treatment for patients who eventually undergo total knee arthroplasty (TKA). However, recent studies have shown a relationship between preoperative injections and adverse outcomes following surgery. The purpose of this study was to characterize the type of intra-articular procedure patients receive in the acute period prior to surgery and determine their association with postoperative periprosthetic joint infection (PJI).

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Background: As total knee arthroplasty (TKA) further transitions toward an outpatient procedure, it becomes important to identify the resource utilization after TKAs at different outpatient facilities. The objective of this study was to determine the 90-day cost of patients who underwent TKAs at an ambulatory surgical center (ASC) or a hospital outpatient department (HOPD).

Methods: An observational cohort study was conducted using the Marketscan database with patients who had a TKA at an ASC or HOPD between January 1st, 2019, and October 2nd, 2021.

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Article Synopsis
  • Recent studies are exploring the feasibility and outcomes of conducting primary total knee arthroplasty (TKA) in outpatient settings, but there's limited information on the costs and outcomes of revision TKA (rTKA).
  • An observational study analyzed data from over 6,500 patients who had rTKA from 2018 to 2020 across various settings, focusing on 30-day costs and 90-day readmission rates.
  • Findings indicate that simpler rTKAs are better suited for outpatient settings, as these procedures have lower costs and decreased rates of readmission and emergency department visits compared to inpatient settings.
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Background: Periprosthetic joint infection (PJI) is a devastating complication after total hip and total knee arthroplasty (THA/TKA). While some guidelines no longer recommend routine use of prophylactic antibiotics for dental procedures, many surgeons continue to prescribe antibiotics for their THA/TKA patients. In a setting of increasing antibiotic resistance, it is important to reduce unnecessary antibiotic use.

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Article Synopsis
  • The study aimed to analyze the types and costs of arthroscopic procedures performed on patients with knee osteoarthritis before total knee arthroplasty (TKA) and their impact on postoperative outcomes.
  • A cohort of 2,904 patients was examined, revealing that 5.2% underwent arthroscopy, primarily meniscectomies, costing an average of $9,716 in the highest payment quartile.
  • While preoperative arthroscopy was linked to increased postoperative stiffness, it didn’t affect the risk of postoperative infections, indicating significant costs without clear benefits for infection rates.*
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Objective: We investigated genetic, epidemiologic, and environmental factors contributing to positive joint cultures.

Design: Retrospective cohort study with whole-genome sequencing (WGS).

Patients: We identified isolates from hip or knee cultures in patients with 1 or more prior corresponding intra-articular procedure at our hospital.

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Importance: The optimal pharmacologic thromboprophylaxis agent after total hip and total knee arthroplasty is uncertain and consensus is lacking. Quantifying the risk of postoperative venous thromboembolism (VTE) and bleeding and evaluating comparative effectiveness and safety of the thromboprophylaxis strategies can inform care.

Objective: To quantify risk factors for postoperative VTE and bleeding and compare patient outcomes among pharmacological thromboprophylaxis agents used after total hip and knee arthroplasty.

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With the recent increase of minor lumbar spine surgeries being performed in the outpatient setting, there is a need for information on factors that contribute to post-operative complications for these surgeries. This was a prospective observational study examining risk factors for self-reported post-operative drainage in patients who underwent lumbar spine surgery. Patient surveys and the hospital's electronic medical records were used to collect data on patient demographic, patient lifestyle, and surgical variables.

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Article Synopsis
  • Researchers studied how and why technology in knee surgeries is becoming popular over time.
  • They looked at surgeries done from 2017 to 2019 and found that only 7.2% used technology, but they expect that number to jump to 50% by 2032.
  • Different parts of the U.S. adopted this technology at different rates, with the West using it the most and the South the least.
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  • A study examined the costs associated with nonoperative treatments for knee osteoarthritis (OA) in patients leading up to total knee arthroplasty (TKA), focusing on data from January 2018 to December 2019.
  • It found that the average cost of these nonoperative procedures was $1,355 per patient, with intra-articular corticosteroid injections being the most common treatment and hyaluronic acid injections being the most expensive.
  • The research revealed that costs varied significantly by gender and geography, highlighting discrepancies that underscore the need for further studies on the effectiveness of these treatments.
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Background: Higher initial opioid dosing increases the risk of prolonged opioid use following total joint arthroplasty (TJA), and the safe amounts to prescribe are unknown. We examined the relationship between perioperative opioid exposure and new persistent usage among opioid-naïve patients after total knee and hip arthroplasty.

Methods: In this retrospective cohort study, 22,310 opioid-naïve patients undergoing primary TJA between 2018 and 2019 were identified within a commercial claims database.

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The impact of the coronavirus 2019 (COVID-19) pandemic on the rate of primary total joint arthroplasty (TJA) peri-prosthetic joint infection (PJI) and superficial surgical site infections (SSI) is currently unknown. The purpose of this multicenter study was to evaluate any changes in the rates of 90-day PJI or 30-day SSI, including trends in microbiology of the infections, during the COVID-19 pandemic compared to the three years prior. An Institutional Review Board-approved, multicenter, retrospective study was conducted with five participating academic institutions across two healthcare systems in the northeastern United States.

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Background: In the United States, patients with late-stage knee osteoarthritis (OA) often undergo several nonoperative treatments and related procedures prior to total knee arthroplasty. The costs of these treatments and procedures are substantial, and the variation in healthcare costs among different groups of patients may exist. The purpose of this study is to examine these costs and determine the drivers of costs in patients with the highest healthcare expenditure.

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Purpose: Routine preoperative urinalysis has been the standard of care for the orthopedic population for decades, regardless of symptoms. Studies have demonstrated antibiotic overuse and low concordance between bacteria cultured from the surgical wound and the urine. Testing and treatment of asymptomatic urinary tract colonization before total joint arthroplasty (TJA) is unnecessary and increases patient risk.

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We performed a retrospective cohort study to identify risk factors for surgical site infection (SSI) in patients with hip and knee arthroplasty in a high-volume orthopedic center with low overall SSI rates. Active smoking and revision arthroplasty both increased the risk for SSI. Former smokers were seen to have a lower SSI risk, demonstrating a potential benefit in implementing mandated smoking secession programs.

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Decontamination of N95 respirators is being used by clinicians in the face of a global shortage of these devices. Some treatments for decontamination, such as some vaporized hydrogen peroxide methods or ultraviolet methods, had no impact on respiratory performance, while other treatments resulted in substantial damage to masks.

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Background: In recent years, there has been a move toward value-based health care. Value is generally defined as outcome divided by cost; however, it is not clear exactly how to define and measure outcomes. In this study, we utilized the Nationwide Inpatient Sample (NIS) to determine how hospital volume and other factors affect quality for patients undergoing total hip and knee arthroplasty.

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Background: Preoperative colonization with Staphylococcus aureus (SA) increases risk of surgical site infection. Screening for SA followed by skin and nasal decolonization can help to reduce the risk of postoperative infections. Risk factors for colonization are, however, not completely understood.

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Background: Disinfection of frequently touched surfaces in the hospital is critical for providing safe care. Because of their complex intricate surfaces, blood pressure cuffs and electrocardiographic telemetry leads may be harder than other equipment to disinfect.

Objective: To determine the effectiveness of 0.

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Door openings in the operating room (OR) have been hypothesized to increase OR environmental contamination. This study measured average colony-forming units (CFU) in the OR as a function of door openings and other potentially important variables. Bacterial settle plates were placed inside and outside of laminar airflow (LAF) by both exit doors, on the instrument table, and on the back instrument table (if applicable) for 48 orthopedic and general surgery procedures.

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