Publications by authors named "Brian H Hoffman"
J Am Chem Soc
October 2024
Article Synopsis
- - Radical enzymes, particularly the glycyl radical enzyme (GRE) family, perform complex chemical reactions crucial for various biological functions, and they all include a key glycine residue that forms a vital α-carbon radical.
- - Researchers found numerous noncanonical GRE homologs that use alanine, serine, or threonine instead of glycine, challenging previous assumptions about radical enzyme structure.
- - These newly identified aminoacyl radical enzymes (AAREs) can generate stable α-carbon radicals when activated by specific partner enzymes and are common in microbial genomes, highlighting their significance and potential for novel chemical reactions.
