Small molecule inhibitors of bromodomain-acetyl-lysine interactions.

Bromodomains are protein modules that bind to acetylated lysine residues. Their interaction with histone proteins suggests that they function as "readers" of histone lysine acetylation, a component of the proposed "histone code". Bromodomain-containing proteins are often found as components of larger protein complexes with roles in fundamental cellular process including transcription.

Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.

Bromodomains are protein modules that bind to acetylated lysine residues and hence facilitate protein-protein interactions. These bromodomain-mediated interactions often play key roles in transcriptional regulation and their dysfunction is implicated in a large number of diseases. The discovery of potent and selective small-molecule bromodomain and extra C-terminal domain bromodomain ligands, which show promising results for the treatment of cancers and atherosclerosis, has promoted intense interest in this area.

Constitutive Extracellular Polysaccharide (EPS) Production by Specific Isolates of Crocosphaera watsonii.

Unicellular dinitrogen (N(2)) fixing cyanobacteria have only recently been identified in the ocean and recognized as important contributors to global N(2) fixation. The only cultivated representatives of the open ocean unicellular diazotrophs are multiple isolates of Crocosphaera watsonii. Although constituents of the genus are nearly genetically identical, isolates have been described in two size classes, large ∼5 μm and small ∼3 μm cell diameters.

Survey of physicians' approach to food allergy, Part 2: Allergens, diagnosis, treatment, and prevention.

Background: Food allergy (FA) practice varies widely.

Objective: To report differences between allergists and nonallergists regarding diagnosis, treatment, and prevention of FA.

Methods: A 2-page questionnaire was mailed to 3,000 allergists and 4,000 nonallergists.

Survey of physicians' approach to food allergy, Part 1: Prevalence and manifestations.

Introduction: Food allergy (FA) prevalence is increasing and is being popularly claimed by the general population.

Objective: To evaluate attitudinal differences between allergists and nonallergists with regard to prevalence, manifestations, offending food component, and time of onset of FA reactions.

Methods: A 2-page questionnaire was mailed to 3,000 members of the American College of Allergy, Asthma and Immunology and 4,000 nonallergists (1,000 each of internists, pediatricians, family practitioners, and otolaryngologists).

Further stable methods for the calculation of partition functions in the superconfiguration approach.

The extension to recursion over holes of the Gilleron and Pain method for calculating partition functions of a canonical ensemble of noninteracting bound electrons is presented as well as a generalization for the efficient computation of collisional line broadening.

Adverse reactions to food additives.

Objectives: To summarize the literature related to the classification of food additives and their reported adverse reactions and to provide a practical approach for evaluation of patients suspected of having such reactions.

Data Sources: Information was derived from selected reviews and original articles published in peer-reviewed journals and from authoritative textbook chapters, supplemented by the clinical experience of the authors.

Study Selection: Priority was given to studies that used blinded, placebo-controlled oral challenges to confirm adverse reactions to food additives.

Generalization of super-transition-array methods to hot dense plasmas by using optimum independent particle reference systems.

The computation of superconfiguration partition functions relies upon independent electron statistics, with electron-electron contributions included as an average first-order correction factor. The decomposition into a first-order correction and reference independent electron system has degrees of freedom not exploited by current methods. We present a derivation for the conventional choice of decomposition and propose a different method for obtaining an optimal decomposition for each superconfiguration.