Publications by authors named "Brian G Salisbury"
Background: Nasal congestion is the most troublesome symptom associated with a variety of upper airway diseases, including allergic rhinitis and the common cold. A better understanding of the mechanisms that regulate nasal cavity caliber may engender the development of novel treatment strategies. It is well accepted that alpha-adrenergic (both alpha(1) and alpha(2)) mechanisms play a fundamental role in the control and maintenance of basal nasal patency.
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- The study focuses on the metabotropic glutamate receptor subtype 5 (mGlu5), which is linked to mental health issues like anxiety and depression, as well as chronic pain.
- Researchers cloned the mouse mGlu5b receptor gene from adult mouse brain and confirmed its expression using a special inducible system, revealing a unique 96 bp sequence.
- The team evaluated the activity of this receptor in lab cells, finding that quisqualic acid was the most effective agonist and identifying several antagonists that could inhibit calcium transients; this cell line will help in future drug testing.