Publications by authors named "Brian E Butler"
Approach to radiation therapy in the Jehovah's Witness patient: An overview.
Rep Pract Oncol Radiother
August 2020
Article Synopsis
- Jehovah's Witnesses don't accept blood products, which can make medical treatments tricky.
- Doctors have to find new ways to treat them to avoid problems like anemia and other side effects.
- This text talks about using special radiation treatments, like intensity modulated radiation therapy (IMRT), to help these patients without harming their blood cells.
Defects in resolving kinetochore-microtubule attachment mistakes during mitosis is linked to chromosome instability associated with carcinogenesis as well as resistance to cancer therapy. Here we report for the first time that tumor suppressor p53-binding protein 1 (53BP1) is phosphorylated at serine 1342 (S1342) by Aurora kinase B both in vitro and in human cells, which is required for optimal recruitment of 53BP1 at kinetochores. Furthermore, 53BP1 staining normally localized on the outer kinetochore, extended to the whole kinetochore when it is merotelically-attached, in concert with mitotic centromere-associated kinesin.
View Article and Find Full Text PDFStereotactic body radiation therapy (SBRT) is a promising treatment option for prostate cancer. Hypofractionation regimens, such as SBRT, may be more advantageous compared with conventional regimens because low α:β ratio of prostate cancer has high sensitivity to dose per fraction. In addition, a smaller and tighter margin with SBRT is expected to provide a low toxicity rate without reducing tumor control.
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